目的 探讨香菊片联合盐酸羟甲唑啉喷雾剂治疗慢性鼻窦炎的临床疗效。方法 选取2018年2月—2019年1月在中国人民解放军联勤保障部队第九0八医院治疗的86例慢性鼻窦炎患者，根据入院号的奇偶性分为对照组和治疗组，每组各43例。对照组给予盐酸羟甲唑啉喷雾剂，一次一侧3喷，早晨和睡前各一次；治疗组在对照组治疗基础上口服香菊片，4片/次，3次/d。两组均经过7 d治疗。观察两组的临床疗效，比较两组治疗前后SF-36评分、鼻部症状VAS评分、内镜Lund-Kennedy评分、血清学指标的变化情况。结果 治疗后，对照组和治疗组的总有效率分别是81.40%、97.67%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组SF-36评分显著升高，而内镜Lund-Kennedy评分、鼻部症状VAS评分均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组SF-36评分显著高于对照组，而内镜Lund-Kennedy评分、鼻部症状VAS评分低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清嗜酸粒细胞阳离子蛋白（ECP）、白细胞介素-12（IL-12）、白细胞介素-17（IL-17）、低氧诱导因子-1α（HIF-1α）、肿瘤坏死因子-α（TNF-α）水平均较治疗前显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组这些血清学指标显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 香菊片联合盐酸羟甲唑啉喷雾剂治疗慢性鼻窦炎具有较好的临床疗效，可有效改善患者临床症状，降低机体炎症因子表达水平，有利于患者生活质量的改善，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Xiangju Tablets combined with Oxymetazoline Hydrochloride Spray in treatment of chronic sinusitis. Methods Patients (86 cases) with chronic sinusitis in 908 Hospital of the Joint Logistics Support Force of PLA from February 2018 to January 2019 were divided into control (43 cases) and treatment (43 cases) groups according to the odd and even number of admission Numbers. Patients in the control group were given Oxymetazoline Hydrochloride Spray, spray 3 times on one side, once in the morning and once before going to bed. Patients in the treatment group were po administered with Xiangju Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, Sf-36 score, nasal symptom VAS score, endoscopic Lund-Kennedy score, and serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.40% and 97.67%, respectively, and there were differences between two groups (P < 0.05). After treatment, Sf-36 score in two groups were significantly increased, but nasal symptom VAS score and endoscopic Lund-Kennedy score were significantly decreased, and there were differences in the same group (P < 0.05). After treatment, Sf-36 score in the treatment group was higher than that in the control group, but nasal symptom VAS score and endoscopic Lund-Kennedy score were lower than that in the control group, and there were differences between two groups (P < 0.05). After treatment, ECP, IL-12, IL-17, HIF-1α, and TNF-α in two groups were significantly decreased, and there were differences in the same group (P < 0.05). After treatment, those serological indicators in the treatment group were lower than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Xiangju Tablets combined with Oxymetazoline Hydrochloride Spray has significant effect in treatment of chronic sinusitis, and can effectively improve the clinical symptoms of patients, and also can reduce the expression level of inflammatory factors in the body, and improve the life quality, which has a certain clinical application value.