目的 探讨辛芳鼻炎胶囊联合罗红霉素治疗鼻窦炎的临床疗效。方法 选取2017年5月—2018年5月在新疆阿克苏地区第一人民医院治疗的鼻窦炎患者98例，根据用药的不同分为对照组（49例）和治疗组（49例）。对照组口服罗红霉素胶囊，0.15 g/次，2次/d；治疗组在对照组基础上口服辛芳鼻炎胶囊，6粒/次，3次/d。两组患者均治疗3月。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状评分、SF-36量表、Lund-Kennedy评分和血清学指标。结果 治疗后，对照组和治疗组临床有效率分别为81.63%、95.92%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者症状评分、Lund-Kennedy评分均显著降低（P<0.05），SF-36生活量表评分显著升高（P<0.05），且治疗组上述评分明显好于对照组（P<0.05）。治疗后，两组血清白细胞介素-1β（IL-1β）、IL-6、IL-17、IL-18、肿瘤坏死因子-α（TNF-α）水平均显著降低（P<0.05），且治疗组上述血清学指标水平明显低于对照组（P<0.05）。结论 辛芳鼻炎胶囊联合罗红霉素治疗鼻窦炎可有效改善患者临床症状，降低机体炎症因子水平，促进患者生活质量提高。

Objective To investigate the clinical efficacy of Xinfang Biyan Capsules combined with roxithromycin in treatment of sinusitis. Methods Patients (98 cases) with sinusitis in the First People's Hospital of Aksu Prefecture from May 2017 to May 2018 were divided into control (49 cases) and treatment (49 cases) groups based on different treatments. Patients in the control group were po administered with Roxithromycin Capsules, 0.15 g/time, twice daily. Patients in the treatment group were po administered with Xinfang Biyan Capsules on the basis of the control group, 6 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, SF-36 scale, Lund-Kennedy scores and the serological indicators in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 81.63% and 95.92%, respectively, and there were differences between two groups (P < 0.05). After treatment, the clinical symptom and Lund-Kennedy scores in two groups were significantly decreased (P < 0.05), but SF-36 scale scores were significantly increased (P < 0.05), and these scores in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the serum IL-1β, IL-6, IL-17, IL-18, and TNF-α levels in two groups was significantly decreased (P < 0.05), and the serological indexes levels in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Xinfang Biyan Capsules combined with roxithromycin in treatment of sinusitis can effectively improve the clinical symptoms, reduce the level of inflammatory factors and improve the quality of life.