目的 探讨复方大青叶合剂联合注射用更昔洛韦治疗儿童流行性腮腺炎的临床疗效。方法 选取2016年5月—2018年5月在天津市宁河区医院治疗的流行性腮腺炎患儿92例，根据用药的差别分为对照组（46例）和治疗组（46例）。对照组静脉滴注注射用更昔洛韦，5 mg/kg加入100 mL生理盐水，1次/12 h；治疗组在对照组的治疗基础上口服复方大青叶合剂，10 mL/次，3次/d。两组患者均治疗7 d。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状消失时间、血清学指标和PAQLQ评分。结果 治疗后，对照组和治疗组临床有效率分别为80.43%和97.83%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者退热、腮腺消肿时间、腮腺疼痛消失时间均明显短于对照组患者，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清C反应蛋白（CRP）、可溶性白介素-2受体（SIL-2R）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均显著降低（P<0.05），且治疗组患者这些血清学指标水平明显低于对照组（P<0.05）。治疗后，两组患者PAQLQ评分显著升高（P<0.05），且治疗组患者PAQLQ评分明显高于对照组（P<0.05）。结论 复方大青叶合剂联合注射用更昔洛韦治疗儿童流行性腮腺炎可有效改善患儿临床症状，降低机体炎症反应，提高患儿生活质量，具有临床推广应用价值。

Objective To investigate the clinical efficacy of Compound Daqingye Mixture combined with ganciclovir in treatment of epidemic mumps in children. Methods Children (92 cases) with epidemic mumps in Tianjin Ninghe District Hospital from May 2016 to May 2018 were divided into control (46 cases) and treatment (46 cases) groups based on different treatments. Children in the control group were iv administered with Ganciclovir for injection, 5 mg/kg added into normal saline 100 mL, once every 12 h. Children in the treatment group were po administered with Compound Daqingye Mixture on the basis of the control group, 10 mL/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, the serological indexes, and PAQLQ scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 80.43% and 97.83%, respectively, and there were differences between two groups (P < 0.05). After treatment, the disappearance time of fever, parotid gland swelling and pain in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the serum CRP, SIL-2R, IL-6 and TNF-α levels in two groups were significantly decreased (P < 0.05), and these serological indexes in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the PAQLQ scores in two groups were significantly increased (P < 0.05), and the scores in the treatment group were significantly higher than that in the control group (P < 0.05). Conclusion Compound Daqingye Mixture combined with ganciclovir in treatment of epidemic mumps in children can effectively improve the clinical symptoms, reduce inflammation and improve the quality of life, which has a clinical application value.