目的 探讨茵山莲颗粒联合注射用醋酸奥曲肽治疗急性胰腺炎的临床疗效。方法 选取2016年1月—2018年9月武汉泰康医院收治的168例急性重症胰腺炎患者作为研究对象，根据随机分组法将患者分为对照组和治疗组，每组各84例。对照组患者给予注射用醋酸奥曲肽，首次剂量0.1 mg，然后以25 μg/h速度静脉泵注，0.6 mg/d。治疗组在对照组治疗的基础上口服茵山莲颗粒，2袋/次，2次/d。两组患者均连续治疗10 d。观察两组患者的临床疗效，同时比较两组治疗前后的临床症状恢复时间、血清炎性因子水平、血尿淀粉酶（AMS）和肠黏膜功能。结果 治疗后，对照组和治疗组的总有效率分别为75.0%、92.9%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组腹痛缓解时间、恶心呕吐消失时间、首次大便时间和住院时间显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清C-反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-8（IL-8）、血尿AMS水平均明显下降，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组血清炎性因子、血尿AMS水平均显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清内毒素、二胺氧化酶（DAO）、尿乳果糖与甘露醇排泄率比值（尿L/M）水平均明显下降，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组内毒素、DAO、尿L/M值均显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 茵山莲颗粒联合注射用醋酸奥曲肽治疗急性胰腺炎疗效显著，能快速促进患者临床症状的恢复，降低炎性因子，改善肠黏膜功能，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Yinshanlian Granules combined with Octreotide Acetate for injection in treatment of acute pancreatitis. Methods Patients (168 cases) with acute pancreatitis in Wuhan Taikang Hospital from January 2016 to September 2018 were randomly divided into control and treatment groups, and each group had 84 cases. Patients in the control group were given Octreotide Acetate for injection, the first dose was 0.1 mg, and then intravenously pumped at 25 μg/h for 0.6 mg/d. Patients in the treatment group were po administered with Yinshanlian Granules on the basis of control group, 2 bags/time, twice daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the clinical symptoms recovery time, serum inflammatory factors, blood and urine AMS, and the intestinal mucosal function in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 75.0% and 92.9%, respectively, and there were differences between two groups (P < 0.05). After treatment, abdominal pain relief time, nausea and vomiting disappearance time, first defecation time, and hospitalization time in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P < 0.05). After treatment, the serum levels of CRP, TNF-α, IL-8, and the blood and urine AMS in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, serum inflammatory factors and the blood and urine AMS levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the serum levels of endotoxin, DAO, and urinary L/M in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the serum endotoxin, DAO, and urinary L/M in the treatment group were lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Yinshanlian Granules combined with Octreotide Acetate for Injection has a significant effect in treatment of acute pancreatitis, can promote the recovery of clinical symptoms, reduce inflammatory factors, and improve the intestinal mucosa function, which has a certain clinical application value.