目的 探讨胃炎宁颗粒联合维酶素片治疗慢性萎缩性胃炎的临床疗效。方法 选取2017年4月—2018年4月在日照市妇幼保健院治疗慢性萎缩性胃炎患者86例，根据就诊号分为对照组（43例）和治疗组（43例）。对照组口服维酶素片，6片/次，3次/d；治疗组在对照组基础上口服胃炎宁颗粒，15 g/次，3次/d。两组患者均治疗4周。观察两组患者临床疗效，同时比较治疗前后两组患者症候积分、SF-36评分、血清炎性因子和血清学指标水平。结果 治疗后，对照组和治疗组临床有效率分别为81.40%和97.67%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组症候积分均显著降低（P<0.05），SF-36评分显著升高（P<0.05），且治疗组上述积分明显好于对照组（P<0.05）。治疗后，两组患者血清白细胞介素1β（IL-1β）、白细胞介素8（IL-8）、肿瘤坏死因子α（TNF-α）、高迁移率族蛋白B1（HMGB1）、胃泌素（GAS）水平均显著降低（P<0.05），血清前列腺素E2（PGE2）、降钙素基因相关肽（CGRP）、胃动素（MTL）、胃蛋白酶原I（PGI）水平均显著升高（P<0.05），且治疗组患者这些指标水平明显好于对照组（P<0.05）。结论 胃炎宁颗粒联合维酶素片治疗慢性萎缩性胃炎可有效改善患者临床症状，降低机体炎症反应和PGE2、CGRP、GAS、MTL、PGI水平。

Objective To explore the clinical effect of Weiyanning Granules combined with vitacoenzyme in treatment of chronic atrophic gastritis. Methods Patients (86 cases) with chronic atrophic gastritis in Rizhao Maternal and Child Health Care Hospital from April 2017 to April 2018 were divided into control (43 cases) and treatment (43 cases) groups based on administration. Patients in the control group were po administered with Vitacoenzyme Tablets, 6 tablets/time, three times daily. Patients in the treatment group were po administered with Weiyanning Granules on the basis of the control group, 15 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the symptom scores, SF-36 scores, the serum inflammatory factors and serological indicators levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 81.40% and 97.67%, respectively, and there were differences between two groups (P < 0.05). After treatment, the symptom scores in two groups were significantly decreased (P < 0.05), but SF-36 scores were significantly increased (P < 0.05), and these scores in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the serum IL-1β, IL-8, TNF-α, HMGB1, and GAS levels in two groups were significantly decreased (P < 0.05), but serum PGE2, CGRP, MTL and PGI levels were significantly increased (P < 0.05), and these indexes levels in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Weiyanning Granules combined with vitacoenzyme can effectively improve the clinical symptoms in treatment of chronic atrophic gastritis, reduce inflammation and improve the levels of PGE2, CGRP, GAS, MTL and PGI.