目的 观察芪蛭胶囊联合辛伐他汀片治疗高脂血症的临床疗效。方法 选取2017年3月—2018年12月天津市第四中心医院收治的236例高脂血症患者作为研究对象，按治疗方案随机将患者分为对照组和治疗组，每组各118例。对照组每晚睡前口服辛伐他汀片，20 mg/次，1次/d；治疗组在对照组治疗的基础上口服芪蛭胶囊，0.8 g/次，3次/d。两组患者均连续用药8周。观察两组患者的临床疗效，比较两组治疗前后的血脂水平、血液流变学指标和血管内皮功能。结果 治疗后，对照组和治疗组的总有效率分别为80.51%、93.22%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）水平明显下降，高密度脂蛋白胆固醇（HDL-C）明显升高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组血脂水平显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组的全血高切黏度（HBV）、全血中切黏度（MBV）、全血低切黏度（LBV）和血浆黏度（PV）水平明显下降，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组血液流变学指标水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组的内皮素-1（ET-1）水平明显下降，一氧化氮（NO）、血管舒张功能（FMD）显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组血管内皮功能显著优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 芪蛭胶囊联合辛伐他汀片治疗高脂血症具有较好的临床疗效，能够显著降低患者血脂水平、促进血管内皮功能和血液流变学明显改善，具有一定的临床推广应用价值。

Objective To observe the clinical effects of Qizhi Capsules combined with Simvastatin Tablets in treatment of hyperlipidemia. Methods Patients (236 cases) with hyperlipidemia in Tianjin 4th Central Hospital from March 2017 to December 2018 were divided into control and treatment groups according to the treatment plan, and each group had 118 cases. Patients in the control group were po administered with Simvastatin Tablets before going to bed, 20 mg/time, once daily. Patients in the treatment group were po administered with Qizhi Capsules on the basis of control group, 0.8 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy, and the blood lipid levels, hemorheology indexes, and vascular endothelial function in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.51% and 93.22%, respectively, and there were differences between two groups (P < 0.05). After treatment, TC, TG, and LDL-C in two groups were significantly decreased, but HDL-C was significantly increased, and there were differences in the same group (P < 0.05). After treatment, blood lipid levels in the treatment group were better than those in the control group, and there were differences between two groups (P < 0.05). After treatment, the levels of HBV, MBV, LBV, and PV in two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). After treatment, the hemorheology indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P< 0.05). After treatment, ET-1 in two groups were significantly decreased, but NO and FMD were increased, and there were differences in the same group (P < 0.05). After treatment, the vascular endothelial function levels in the treatment group were better than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Qizhi Capsules combined with Simvastatin Tablets has a good clinical effect in treatment of hyperlipidemia, can significantly reduce blood lipid levels, and promote vascular endothelial function and hemorheology, which has a certain clinical application value.