目的 分析唑吡坦不良反应的发生情况及特点，为临床安全用药提供参考。方法 检索中国生物医学文献数据库、中国科学引文数据库、中文科技期刊全文数据库（维普）、中国学术期刊（网络版）、万方数字化期刊全文库、PubMed数据库有关唑吡坦不良反应个案报道，进行回顾性分析。结果 共纳入文献病例55例，男女比例1：1.12，年龄 ≥ 65岁者24人，构成比为43.64%；不良反应多发生于服药后1 d内，共34例，构成比为61.82%；累及系统/器官主要以中枢神经系统为主，表现为睡行症、精神异常、幻觉、睡眠饮食障碍等，其次为泌尿生殖系统。结论 临床应高度重视唑吡坦的不良反应，加强用药监护，确保用药安全。

Objective To analyze the occurrence and characteristics of adverse reactions induced by zolpidem in order to provide reference for clinical safe medication. Methods China Biology Medicine disc, Chinese Science Citation Database, Chinese Science and Technology Journal Full-text Database (VIP), Chinese Academic Journal (online), Wangfang Database, and PubMed Database were searched for adverse drug reactions induced by zolpidem, and were made a retrospective analysis. Results Totally 55 cases were included in the literature, and the ratio of male to female was 1:1.12. Patients older than 65 years accounted for 43.64%. Patients (34 cases) had adverse reactions within 1 d after taking the medicine, constituting 61.28%. The system/organs involved were mainly the central nervous system, which was mainly for somnambulism, mental disorders, hallucinations, sleep and eating disorders, etc, followed by the urogenital system. Conclusion Adverse reactions induced by zolpidem should be highly valued to strengthen medication custody and ensure drug safety.