目的 探讨黄葵胶囊联合海昆肾喜治疗慢性肾病的有效性和安全性。方法 选取2015年1月-2018年1月中国人民解放军总医院收治的慢性肾病患者113例，随机分为对照组（56例）和治疗组（57例）。对照组患者口服海昆肾喜胶囊，2粒/次，3次/d。治疗组患者在对照组基础上口服黄葵胶囊，5粒/次，3次/d。两组均连续治疗3个月。观察两组患者临床疗效，同时比较治疗前后两组患者血肌酐（Scr）、尿素氮（BUN）、24 h尿蛋白定量（Upro）、肾小球滤过率评估值（eGFR）、白细胞介素-6（IL-6）、超敏C-反应蛋白（hs-CRP）和肿瘤坏死因子-α（TNF-α）水平。结果 治疗后，对照组和治疗组临床有效率分别为78.57%和92.98%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者Scr、BUN、Upro、IL-6、hs-CRP和TNF-α水平显著降低，eGFR水平显著升高，同组治疗前后比较差异具有统计学意义（P<0.05），且治疗组各指标明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 黄葵胶囊联合海昆肾喜可有效改善患者的肾功能及机体炎性状态，疗效安全显著，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy and safety of Huangkui Capsules combined with Haikun Shenxi Capsules in treatment of chronic kidney disease. Methods Patients (113 cases) with chronic kidney disease in Chinese PLA General Hospital from January 2015 to January 2018 were randomly divided into control (56 cases) and treatment (57 cases) groups. Patients in the control group were po administered with Haikun Shenxi Capsules, 2 grains/time, three times daily. Patients in the treatment group were po administered with Huangkui Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the Scr, BUN, 24 h Upro, eGFR, IL-6, hs-CRP, and TNF-α levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 78.57% and 92.98% respectively, and there were differences between two groups (P < 0.05). After treatment, the Scr, BUN, Upro, IL-6, hs-CRP, and TNF-α levels in two groups were significantly decreased, but eGFR levels were significantly increased, and the difference was statistically significant in the same group (P < 0.05), and these indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Huangkui Capsules combined with Haikun Shenxi Capsules in treatment of chronic kidney disease can effectively improve kidney function and inflammatory state, has significantly safety and clinical efficacy, which has a certain clinical application value.