目的 探讨金莲花胶囊联合大蒜素胶囊治疗复发性口腔溃疡的临床效果。方法 选取2016年1月-2017年10月河南科技大学第一附属医院收治的复发性口腔溃疡患者114例，随机分成对照组（57例）和治疗组（57例）。对照组口服大蒜素胶囊，2粒/次，3次/d。治疗组在对照组基础上口服金莲花胶囊，4粒/次，3次/d。两组患者均连续治疗3个月。观察两组患者临床疗效，同时比较治疗前后两组患者平均溃疡期、疼痛指数、14项口腔健康影响程度量表（OHIP-14）评分及肿瘤坏死因子-α（TNF-α）、白介素-10（IL-10）、超氧化物歧化酶（SOD）水平。结果 治疗后，对照组和治疗组临床有效率分别为78.9%和93.0%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组平均溃疡期较治疗前显著缩短（P<0.05），疼痛指数显著降低（P<0.05），且治疗组平均溃疡期和疼痛指数比对照组改善更明显（P<0.05）。治疗后，两组患者OHIP-14各项目评分及总分均显著降低（P<0.05），且治疗组患者评分明显低于对照组（P<0.05）。治疗后，两组患者血清TNF-α、IL-10浓度显著降低（P<0.05），SOD水平显著升高（P<0.05），且治疗后治疗组TNF-α、IL-10、SOD水平明显好于对照组（P<0.05）。结论 金莲花胶囊联合大蒜素胶囊治疗复发性口腔溃疡可缩短患者溃疡期，缓解疼痛，提高机体抗氧化能力，改善生活质量。

Objective To investigate the clinical effect of Jinlianhua Capsules combined with Garlicin Capsules in treatment of Recurrent Oral Ulcer. Methods Patients (114 cases) with Recurrent Oral Ulcer in the First Affiliated Hospital of Henan University of Science and Technology from January 2016 to October 2017 were randomly divided into control (57 cases) and treatment (57 cases) groups. Patients in the control group were po administered with Garlicin Capsules, 2 grains/time, three times daily. Patients in the treatment group were po administered with Jinlianhua Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the average time of ulceration, pain indexes, OHIP-14 scores, and TNF-α, IL-10 and SOD levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 78.9% and 93.0% respectively, and there were differences between two groups (P < 0.05). After treatment, the average time of ulceration in two groups were significantly shortened (P < 0.05), pain indexes were significantly decreased (P < 0.05), and the average time of ulceration, pain indexes in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the each item score of OHIP-14 and total scores in two groups were significantly decreased (P < 0.05), and these scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the serum concentration of TNF-α and IL-10 in two groups were significantly decreased (P < 0.05), but SOD levels were significantly increased (P < 0.05), and the TNF-α, IL-10 and SOD levels in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Jinlianhua Capsules combined with Garlicin Capsules in treatment of recurrent oral ulcer can safely and effectively shorten the ulceration period, relieve pain, improve the body's antioxidant capacity and the quality of life.