目的 探讨平消胶囊联合丙氨瑞林治疗子宫肌瘤的临床有效性与安全性。方法 选取2015年12月-2017年12月津中医药大学第一附属医院收治的子宫肌瘤患者90例，根据患者入院顺序分成对照组和治疗组，每组各45例。对照组患者肌肉注射注射用丙氨瑞林，150 μg/次溶解于2 mL生理盐水；治疗组在对照组基础上口服平消胶囊，5粒/次，3次/d。两组患者均连续治疗12周。观察两组患者临床疗效，同时比较治疗前后两组患者子宫肌瘤体积、月经量及生活质量、血清胰岛素样生长因子Ⅰ（IGF-Ⅰ）、血清胰岛素样生长因子Ⅱ（IGF-Ⅱ）、抗缪勒管激素（AMH）和性激素水平。结果 治疗后，对照组和治疗组临床有效率分别为80.00%和95.56%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者子宫肌瘤体积和月经量均显著降低（P<0.05），生活质量评分显著升高（P<0.05），且治疗组患者各指标明显优于对照组（P<0.05）。治疗后，两组患者血清IGF-I、IGF-Ⅱ、AMH、雌二醇（E₂）、促卵泡刺激素（FSH）和黄体生成素（LH）水平均显著降低（P<0.05），且治疗组IGF-I、IGF-Ⅱ、E₂、FSH和LH水平明显低于对照组，AMH水平高于对照组（P<0.05）。结论 平消胶囊联合丙氨瑞林治疗子宫肌瘤临床有效率高、安全性好，同时还能够改善患者的生活质量，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy and safety of Pingxiao Capsules combined with alarelin in treatment of hysteromyoma. Methods Patients (90 cases) with hysteromyoma in First Teaching Hospital of Tianjin University of TCM from December 2015 to December 2017 were divided into control and treatment groups according to the order of hospitalization, and each group had 45 cases. Patients in the control group were intramuscular injection administered with Alarelin for injection, 150 μg/time dissolved in 2 mL normal saline. Patients in the treatment group were po administered with Pingxiao Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the uterine fibroid volume, the menstrual volume and quality of life, IGF-Ⅰ, IGF-Ⅱ, AMH and sex hormone levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.00% and 95.56% respectively, and there were differences between two groups (P < 0.05). After treatment, the uterine fibroid volume and the menstrual volume in two groups was significantly decreased (P < 0.05), but the quality of life was significantly increased (P < 0.05), and these indicators in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the serum levels of IGF-I, IGF-Ⅱ, AMH, E2, FSH and LH in two groups were significantly decreased (P < 0.05). IGF-I, IGF-Ⅱ, E2, FSH and LH levels in the treatment group were significantly lower than those in the control group, but AMH level in the treatment group was significantly higher than that in the control group, and there were differences between two groups (P < 0.05). Conclusion Pingxiao Capsules combined with alarelin in treatment of hysteromyoma is clinically effective and safe, and can improve the quality of life, which has a certain clinical application value.

国家中医药管理局中医学术流派传承工作室建设项目（LPGZS2012-04）