目的 探讨金莲花颗粒联合利巴韦林颗粒治疗小儿手足口病的临床疗效。方法 选取2015年11月-2016年10月于三峡大学人民医院收治的108例手足口病患儿作为研究对象，采用数字表法将患者随机分为对照组和治疗组，每组各54例。对照组患儿口服利巴韦林颗粒，15 mg/kg，3次/d。治疗组在对照组治疗的基础上口服金莲花颗粒，3次/d，年龄1~3岁，1袋/次；3岁以上，2袋/次。两组患儿均持续治疗7 d。观察两组患者的临床疗效，比较两组的临床症状改善时间和血清学指标。结果 治疗后，对照组和治疗组的总有效率分别为83.3%、92.6%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组的疱疹康复、口腔溃疡消退、体温恢复、食欲恢复和住院时间均显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患儿肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）、丙氨酸氨基转移酶（ALT）和血清干扰素-γ（IFN-γ）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组血清学指标水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 金莲花颗粒联合利巴韦林颗粒治疗小儿手足口病能明显改善患儿临床症状和血清学指标，且安全性好，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Jinlianhua Granules combined with Ribavirin Granules in treatment of hand foot and mouth disease in children. Methods Children (108 cases) with hand foot and mouth disease in Sanxia University People's Hospital from November 2015 to October 2016 were randomly divided into control and treatment groups, and each group had 54 cases. Children in the control group were po administered with Ribavirin Granules, 15 mg/kg, three times daily. Children in the treatment group were po administered with Jinlianhua Granules on the basis of the control group, aged 1-3 years, 1 bag/time, and over 3 years old, 2 bags/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the time of clinical symptoms improvement and serological indexes in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 83.3% and 92.6%, respectively, and there were differences between two groups (P < 0.05). After treatment, the herpes recovery, oral ulcer subsidence, body temperature recovery, appetite recovery, and hospitalization time in the treatment group were significantly shorter than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TNF-α, hs-CRP, ALT, and IFN-γ in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the serological indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Jinlianhua Granules combined with Ribavirin Granules in treatment of hand foot and mouth disease in children can significantly improve the clinical symptoms and serological indexes, with good safety, which has a certain clinical application value.