目的 观察辅酶Q10片联合富马酸比索洛尔片治疗慢性心力衰竭的临床疗效。方法 选取2016年3月-2018年3月在海南省人民医院治疗的142例慢性心力衰竭患者作为研究对象，按照随机数字表法将所有患者分为对照组和治疗组，每组各71例。对照组患者口服富马酸比索洛尔片，47.5 mg/次，1次/d。治疗组在对照组的基础上口服辅酶Q10片，10 mg/次，3次/d。两组患者均治疗28 d。观察两组患者的临床疗效，同时比较两组治疗前后的心功能指标、NYHA分级、6 min步行运动试验（6 MWD）、嗜铬粒细胞蛋白A（CgA）和可溶性糖蛋白130（Sgp130）水平。结果 治疗后，对照组和治疗组的总效率分别为80.28%、92.96%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者左心室收缩期末内径（LVESD）、左心室舒张末期内径（LVEDD）均明显降低，左心室射血分数（LVEF）显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组的心功能指标显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者NYHA分级明显降低，6 MWD显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组NYHA分级显著低于对照组，6 MWD显著高于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者CgA和Sgp130水平均显著下降，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组CgA和Sgp130水平均明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 辅酶Q10片联合富马酸比索洛尔片治疗慢性心力衰竭具有良好的临床疗效，可显著改善患者的心功能，延缓患者心肌重构，且安全性高，具有一定的临床推广应用价值。

Objective To observe the clinical effect of Coenzyme Q10 Tablets combined with Bisoprolol Fumarate Tablets in treatment of chronic heart failure. Methods Patients (142 cases) with chronic heart failure in Hainan General Hospital from March 2016 to March 2018 were divided into control and treatment group according to the random number table method, and each group had 71 cases. Patients in the control group were po administered with Bisoprolol Fumarate Tablets, 47.5 mg/time, once daily. Patients in the treatment group were po administered with Coenzyme Q10 Tablets on the basis of the control group, 10 mg/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical efficacy was evaluated, and cardiac function indexes, NYHA classification, 6 MWD, CgA and Sgp130 levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.28% and 92.96%, respectively, and there were differences between two groups (P < 0.05). After treatment, LVESD and LVEDD in two groups were significantly decreased, but LVEE in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, cardiac function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, NYHA classification in two groups were significantly decreased, but 6 MWD in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, NYHA classification in the treatment group were significantly lower than those in the control group, but 6 MWD in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). After treatment, CgA and Sgp130 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, CgA and Sgp130 levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Coenzyme Q10 Tablets combined with Bisoprolol Fumarate Tablets has a good clinical effect in treatment of chronic heart failure, can significantly improve the cardiac function, delay the myocardial remodeling, with high safety, which has a certain clinical application value.