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[摘要]
目的 了解解放军总医院抗癫痫药物的应用情况与趋势。方法 采用世界卫生组织(WHO)推荐的以限定日剂量(DDD)为指标的分析方法,对2015-2017年解放军总医院抗癫痫药物的用药金额、用药频度(DDDs)、日均费用(DDC))和排序比(B/A)等进行统计分析。结果 左乙拉西坦、奥卡西平和丙戊酸钠的用药金额始终处于前3位,加巴喷丁的用药金额逐渐上升,托吡酯的用药金额逐渐下降;用药频度(DDDs)排序列前3位的是左乙拉西坦、奥卡西平和丙戊酸钠,左乙拉西坦的DDDs逐年上升,2017年已跃居至第1位;2015-2016年各种抗癫痫药物的DDC较为稳定,2016-2017年各种抗癫痫药物的DDC开始略有下降;除拉莫三嗪的排序比值始终小于1.00,其他抗癫痫药物的B/A均在1.00以上波动。结论 解放军总医院抗癫痫治疗以新型抗癫痫药物为主,其中左乙拉西坦和奥卡西平具有很好的市场前景。
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[Abstract]
Objective To investigate the utilization and tendency of antiepileptic drugs in PLA General Hospital.Methods The consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) of antiepileptic drugs in PLA General Hospital from 2015 to 2017 were analyzed retrospectively by defined daily doses (DDD) recommended by WHO.Results Sale amounts of levetiracetam, oxcarbazepine, and sodium valproate were always in the top three. Consumption sum of gabapentin was increasing during three years, while consumption sum of topiramate was decreasing. DDDs of levetiracetam, oxcarbazepine, and sodium valproate were ranked the top three. DDDs of levetiracetam increased year by year and leaped into the first place in 2017. DDC of various antiepileptic drugs was relatively stable from 2015 to 2016, and DDC of various antiepileptic drugs began to decline slightly from 2015 to 2016. B/A of lamotrigine was always less than 1.00, while B/A of other antiepileptic drugs fluctuated above 1.00.Conclusion The application of antiepileptic drugs in PLA General Hospital is more reasonable. At present, new anti-epileptic drugs are used most, and levetiracetam and oxcarbazepine have good market prospects.
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[基金项目]
国家十三五“重大新药创制”科技重大专项资助项目(2018ZX09201013)