目的 探讨四妙丸联合苯溴马隆片治疗痛风性关节炎的临床疗效。方法 选取2016年6月-2018年6月保康县人民医院收治的70例痛风性关节炎患者作为研究对象，将所有患者随机分为对照组和治疗组，每组各35例。对照组患者口服苯溴马隆片，1片/次，1次/d。治疗组在对照组治疗的基础上口服四妙丸，1袋/次，2次/d。两组患者连续治疗2周。观察两组患者的临床疗效，同时比较两组治疗前后的WOMAC评分、生化指标、血清炎性因子水平。结果 治疗后，治疗组的总有效率为94.29%，显著高于对照组的80.00%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组WOMAC评分均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后治疗组WOMAC评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者尿酸（UA）水平显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后治疗组UA水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。两组天冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）水平差异无统计学意义。治疗后，两组患者的血清超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后治疗组炎性因子水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 四妙丸联合苯溴马隆片治疗痛风性关节炎具有较好的临床疗效，可改善患者临床症状，降低尿酸水平，具有一定的临床推广价值。

Objective To explore the clinical effect of Simiao Pills combined with Benzbromarone Tablets in treatment of gouty arthritis.Methods Patients (70 cases) with gouty arthritis in Baokang County People's Hospital from June 2016 to June 2018 were randomly divided into control and treatment groups, and each group had 35 cases. Patients in the control group were po administered with Benzbromarone Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Simiao Pills on the basis of the control group, 1 bag/time, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the WOMAC scores, biochemical indexes, and serum inflammatory factors in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the treatment group was 94.29%, which was significantly higher than 80.00% in the control group, and there were differences between two groups (P<0.05). After treatment, WOMAC scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, WOMAC scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, UA levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, UA levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). There waere no significant difference in the levels of AST and ALT between two groups. After treatment, the serum levels of hs-CRP, TNF-α, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, serum inflammatory factors level in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05).Conclusion Simiao Pills combined with Benzbromarone Tablets has good clinical effect in treatment of gouty arthritis, can improve the clinical symptoms, and reduce the uric acid level, which has a certain clinical application value.