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[摘要]
目的 探讨肾衰宁胶囊联合硫辛酸注射液治疗糖尿病肾病的临床疗效。方法 选取2017年6月-2018年8月在中国人民解放军北部战区空军医院就诊的糖尿病肾病患者92例作为研究对象,按照随机数字表法分为对照组和治疗组,每组各46例。对照组静脉滴注硫辛酸注射液,0.6 g/次,1次/d。治疗组在对照组治疗的基础上口服肾衰宁胶囊,6粒/次,3次/d。两组患者均连续治疗2周。观察两组的临床疗效,比较两组的肾功能指标、炎性因子水平和血糖水平。结果 治疗后,对照组和治疗组的总有效率分别为78.26%、93.48%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者的尿白蛋白排泄率(UAER)、血肌酐(Scr)、β2-微球蛋白(β2-MG)、微量白蛋白(mALB)水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组的UAER、Scr、β2-MG、mALB水平比对照组低,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者的超氧化物歧化酶(SOD)水平显著升高,而丙二醛(MDA)、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平均显著降低,同组治疗前后差异有具有统计学意义(P<0.05);且治疗后治疗组的SOD水平比对照组高,MDA、CRP、IL-6水平均比对照组低,两组差异具有统计学意义(P<0.05)。治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白同组治疗前后比较差异无统计学意义,两组比较差异也无统计学意义。结论 肾衰宁胶囊联合硫辛酸注射液治疗糖尿病肾病的疗效确切,能改善肾功能,调节炎性因子水平,安全性较好,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Shenshuaining Capsules combined with Lipoic Acid Injection in treatment of diabetic nephropathy.Methods Patients (92 cases) with diabetic nephropathy in the Air Force Hospital of the Northern War Zone of the Chinese People's Liberation Army from June 2017 to August 2018 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were iv administered with Lipoic Acid Injection, 0.6 g/time, once daily. Patients in the treatment group were po administered with Shenshuaining Capsules on the basis of the control group, 6 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and renal function indexes, inflammatory factor levels, and blood glucose levels in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 78.26% and 93.48%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of UAER, Scr, β2-MG, and mALB in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And renal function indexes, in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of SOD in two groups were significantly increased, but the levels of NDA, CRP, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the inflammatory factor levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, there was no significant difference in fasting blood glucose, postprandial blood glucose, and glycosylated hemoglobin between two groups.Conclusion Shenshuaining Capsules combined with Lipoic Acid Injection has clinical curative effect in treatment of diabetic nephropathy, can improve renal function, and regulate inflammatory factor levels, with good safety, which has a certain clinical application value.
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