目的 探讨天芪降糖胶囊联合沙格列汀治疗2型糖尿病的临床效果。方法 选取2014年1月-2017年12月南阳市第一人民医院收治的2型糖尿病患者84例，随机分成对照组（42）和治疗组（42例）。对照组口服沙格列汀片，1片/次，1次/d。治疗组在对照组基础上口服天芪降糖胶囊，5粒/次，3次/d。两组均连续治疗8周。观察两组患者临床疗效，同时比较治疗前后两组患者症候积分、空腹血糖（FPG）、餐后2 h血糖（2 h PG）和糖化血红蛋白（HbA1c）血浆水平及胰岛素抵抗指数（HOMA-IR）、胰岛β细胞功能指数-β（HOMA-β）、肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）和中性粒细胞/淋巴细胞比值（NLR）水平。结果 治疗后，对照组临床有效率为76.2%，显著低于治疗组的92.9%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者各项症候积分及总分均显著减少（P<0.05），且治疗组明显低于对照组（P<0.05）。治疗后，两组患者FPG、2 h PG和HbA1c血浆水平显著降低（P<0.05），且治疗组上述血糖参数水平明显低于对照组（P<0.05）。治疗后，两组患者HOMA-IR值和血清TNF-α、IL-6浓度及外周血NLR值均显著降低（P<0.05），HOMA-β值显著升高（P<0.05），且治疗组上述指标水平明显好于对照组（P<0.05）。结论 天芪降糖胶囊联合沙格列汀治疗2型糖尿病能明显减轻患者高血糖症状，维持血糖稳定，改善胰岛功能及体内微炎症状态，延缓病程进展。

Objective To investigate the clinical effect of Tianqi Jiangtang Capsules combined with saxagliptin in treatment of type 2 diabetes mellitus.Methods Patients (84 cases) with type 2 diabetes mellitus in Nanyang First People's Hospital from January 2014 to December 2017 were randomly divided into control (42 cases) and treatment (42 cases) groups. Patients in the control group were po administered with Saxagliptin Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Tianqi Jiangtang Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the symptom scores, FPG, 2 h PG and HbA1c, HOMA-IR, HOMA-β, TNF-α, IL-6 and NLR levels in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the control group was 76.2%, which was significantly lower than 92.9% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the symptom scores in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the FPG, 2 h PG and HbA1c levels in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the HOMA-IR value, serum NF-α and IL-6 concentration, and NLR value of peripheral blood in two groups were significantly decreased (P<0.05), but HOMA-β value were significantly increased (P<0.05), and these indexes in the treatment group were significantlybetter than those in the control group (P<0.05).Conclusion Tianqi Jiangtang Capsules combined with saxagliptin in treatment of type 2 diabetes mellitus can significantly reduce the hyperglycemia symptoms, maintain blood glucose stability, improve islet function and microinflammation state, and delay the progression of the disease.