目的 探讨降糖宁胶囊联合艾塞那肽治疗2型糖尿病的临床疗效。方法 选取2017年6月-2018年6月在驻马店市中心医院治疗的2型糖尿病患者96例，依据住院号分成对照组（48例）和治疗组（48例）。对照组静脉注射注射用艾塞那肽微球，2 mg/次，1次/周；治疗组在对照组基础上口服降糖宁胶囊，2.4 g/次，3次/d。两组均治疗4周。观察两组患者临床疗效，同时比较治疗前后两组患者空腹血糖（FBG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）、胰岛素（FINS）、HOMA-β、HOMA-IR、血清学指标和氧化应激指标。结果 治疗后，对照组和治疗组临床总有效率分别为81.25%和97.92%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组FPG、2 h PG、HbAlc、FINS、单核细胞趋化蛋白-1（MCP-1）、白细胞介素-6（IL-6）、前颗粒体蛋白（PGRN）、肿瘤坏死因素-α（TFN-α）、γ-谷氨酰转移酶（γ-GT）水平均显著下降（P<0.05），且治疗组上述指标明显低于对照组（P<0.05）。治疗后，两组HOMA-β、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）显著升高（P<0.05），HOMA-IR和丙二醛（MDA）显著降低（P<0.05），且治疗组这些指标明显好于对照组（P<0.05）。结论 降糖宁胶囊联合艾塞那肽治疗2型糖尿病可有效控制患者血糖水平，降低机体炎症反应，改善机体氧化应激状态，改善胰岛素抵抗及提高胰岛素敏感性，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Jiangtangning Capsules combined with exenatide in treatment of type 2 diabetes mellitus.Methods Patients (96 cases) with type 2 diabetes mellitus in Zhumadian Central Hospital from June 2017 to June 2018 were divided into control (48 cases) and treatment (48 cases) groups according to admission number. Patients in the control group were iv administered with Exenatide Microspheres for injection, 2 mg/time, once weekly. Patients in the treatment group were po administered with Jiangtangning Capsules on the basis of the control group, 2.4 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the FBG, 2 h PG, HbA1c, FINS, HOMA-β, HOMA-IR, serological indexes, and oxidative stress indexes in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the control and treatment groups was 81.25% and 97.92% respectively, and there were differences between two groups (P<0.05). After treatment, the FPG, 2 h PG, HbAlc, FINS, MCP-1, PGRN, γ-GT, IL-6, and TNF-α levels in two groups were significantly decreased (P<0.05), and these indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the HOMA-β, GSH-Px and SOD in two groups were significantly increased (P<0.05), but HOMA-IR and MDA were significantly decreased (P<0.05), and these indicators in the treatment group were significantly better than those in the control group (P<0.05).Conclusion Jiangtangning Capsules combined with exenatide in treatment of type 2 diabetes mellitus can effectively control blood glucose levels, reduce inflammation, improve oxidative stress, insulin resistance and insulin sensitivity, which has a certain clinical application value.