目的 评价小儿宝泰康颗粒联合头孢呋辛酯治疗小儿上呼吸道感染患者的安全性与有效性。方法 选取新乡市妇幼保健院于2016年7月-2017年7月收治的小儿上呼吸道感染患者154例，随机分成对照组和治疗组，每组各77例。对照组患儿口服头孢呋辛酯分散片，0.125 g/次，2次/d；治疗组患儿在对照组用药基础上口服小儿宝泰康颗粒，3岁以下儿童4 g/次，3~12岁儿童8 g/次，3次/d。两组患儿均连续用药7 d。观察两组患者临床疗效，同时比较治疗前后两组患者症状积分和炎症指标水平。结果 治疗后，对照组临床有效率为85.71%，显著低于治疗组的96.10%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者症状积分，血清淀粉样蛋白A（SAA）、降钙素原（PCT）、超敏C反应蛋白（hs-CRP）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组症状积分和炎症指标水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 小儿宝泰康颗粒联合头孢呋辛酯治疗小儿上呼吸道感染疗效确切，安全性好，且能够显著减轻患者机体的炎症反应，具有一定的临床推广应用价值。

Objective To evaluate the safety and efficacy of Xiaoer Baotaikang Granules combined with cefuroxime axetil in treatment of upper respiratory tract infection in children.Methods Children (154 cases) with upper respiratory tract infection in Xinxiang Maternal and Child Health Hospital from July 2016 to July 2017 were randomly divided into control and treatment groups, and each group had 77 cases. Children in the control group were po administered with Cefuroxime Axetil Dispersible Tablets, 0.125 g/time, twice daily. Children in the treatment group were po administered with Xiaoer Baotaikang Granules on the basis of the control group, 4 g/time for children under 3 years of age, 8 g/time for 3 — 12 years of age, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the symptom scores, the inflammatory markers levels in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the control group was 85.71%, which was significantly lower than 96.10% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the symptom scores, serum SAA, PCT and hs-CRP levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the symptom scores and inflammatory markers levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05).Conclusion Xiaoer Baotaikang Granules combined with cefuroxime axetil has significant effect and high safe in treatment of upper respiratory tract infection in children, and can significantly reduce the inflammatory response, which has a certain clinical application value.