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[摘要]
目的 探讨消癌平注射液联合顺铂和卡培他滨片同步放化疗治疗局部晚期鼻咽癌的临床疗效。方法 选取2013年2月-2017年5月在内蒙古林业总医院进行治疗的局部晚期鼻咽癌患者76例,根据用药的差别分为对照组(38例)和治疗组(38例)。对照组静脉滴注顺铂注射液,第1天80 mg/m2,同时口服卡培他滨片1 000 mg/m2,2次/d,每3周为1个疗程。治疗组在对照组基础上静脉滴注消癌平注射液,40 mL加入50%葡萄糖液500 mL,10 d为1个疗程,1个月重复1次,至同步放化疗结束。两组患者治疗9周后进行效果评价。观察两组患者临床疗效,同时比较治疗前后两组患者肿瘤标志物水平、血清学指标和QLQ-C30评分。结果 治疗后,对照组客观缓解率和临床获益率分别为42.11%和78.95%,均分别显著低于治疗组的65.79%和92.11%,两组患者比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清巨噬细胞炎性蛋白-3α(MIP-3α)、糖抗原125(CA125)、细胞角蛋白19片段(CYFRA21-1)、血管内皮生长因子(VEGF)、骨碱性磷酸酶(B-ALP)、基质金属蛋白酶-9(MMP-9)、表皮细胞生长因子(EGF)和表皮细胞生长因子受体(EGFR)水平均显著降低(P<0.05),且治疗组这些肿瘤标志物和血清学指标水平明显低于对照组(P<0.05)。治疗后,两组患者QLQ-C30量表各评分均明显升高(P<0.05),且治疗组患者QLQ-C30各项评分明显高于对照组(P<0.05)。结论 消癌平注射液联合顺铂和卡培他滨片同步放化疗治疗局部晚期鼻咽癌够降低机体肿瘤标志物水平,提高患者生活质量,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Xiaoaiping Injection combined with cisplatin and capecitabine in treatment of locally advanced nasopharyngeal carcinoma.Methods Patients (76 cases) with locally advanced nasopharyngeal carcinoma in Inner Mongolia Forestry General Hospital from February 2013 to May 2017 were divided into control (38 cases) and treatment (38 cases) groups according to different treatments. Patients in the control group were iv administered with Cisplatin Injection, 80 mg/m2 for the 1st day, and at the same time they were po administered with Capecitabine Tablets, 1 000 mg/m2, twice daily, and every 3 weeks was a course of treatment. Patients in the treatment group were iv administered with Xiaoaiping Injection on the basis of the control group, 40 mL added into 50% glucose solution 500 mL, and 10 d was a course of treatment, repeat once a month until the end of radiotherapy and chemotherapy. Patients in two groups were treated for 9 weeks. After treatment, the clinical efficacy was evaluated, and the tumor markers levels, the serological indexes and QLQ-C30 scores in two groups before and after treatment were compared.Results After treatment, the objective reaction rate and clinical benefit rate in the control group were 42.11% and 78.95%, which were significantly lower than 65.79% and 92.11% in the treatment group, respectively, and there were differences between two groups (P<0.05). After treatment, the serum MIP-3α, CA125, CYFRA21-1, VEGF, B-ALP, MMP-9, EGF and EGFR levels in two groups were significantly decreased (P<0.05), and these tumor markers and serological indexes levels in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the QLQ-C30 scores in two groups were significantly increased (P<0.05), and the QLQ-C30 scores in the treatment group were significantly higher than those in the control group (P<0.05).Conclusion Xiaoaiping Injection combined with cisplatin and capecitabine in treatment of locally advanced nasopharyngeal carcinoma can reduce the level of tumor markers and improve the quality of life, which has a certain clinical application value.
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