目的 研究银丹心脑通软胶囊联合普罗布考片治疗脑动脉粥样硬化的临床疗效。方法 选取2015年9月-2017年9月辽宁省人民医院收治的脑动脉粥样硬化患者120例作为研究对象，将所有患者随机分为对照组和治疗组，每组各60例。对照组早、晚餐时口服普罗布考片，0.5 g/次，2次/d。治疗组患者在对照组治疗的基础上口服银丹心脑通软胶囊，4粒/次，3次/d。两组患者持续治疗12周。观察两组的临床疗效，比较两组的疾病相关指标和血脂水平。结果 治疗后，对照组和治疗组的总有效率分别为83.33%、96.67%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者颈动脉内膜中膜厚度、斑块面积和血管搏动指数显著下降，而动脉血流速度明显升高，同组治疗前后差异具有统计学意义（P<0.05）；并且治疗组患者疾病相关指标明显优于对照组，两组差异具有统计学意义（P<0.05）。治疗后，两组患者三酰甘油（TG）、总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）水平显著下降，而高密度脂蛋白胆固醇（HDL-C）水平显著升高，同组治疗前后差异具有统计学意义（P<0.05）；并且治疗组血脂水平的明显优于对照组，两组差异具有统计学意义（P<0.05）。结论 银丹心脑通软胶囊联合普罗布考片治疗脑动脉粥样硬化具有较好的临床疗效，能够改善临床症状，降低血脂水平，安全性较高，具有一定的临床推广应用价值。

Objective To study the clinical effects of Yindan Xinnaotong Soft Capsules combined with Probucol Tablets in treatment of cerebral atherosclerosis.Methods Patients (120 cases) with cerebral atherosclerosis in Liaoning People's Hospital from September 2015 to September 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Probucol Tablets, 0.5 g/time, twice daily. Patients in the treatment group were po administered with Yindan Xinnaotong Soft Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and disease-related indicators and blood lipid levels in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 83.33% and 96.67%, respectively, and there was difference between two groups (P<0.05). After treatment, the carotid intima-media thickness, the plaque area, and the vascular pulsation index in two groups were significantly decreased, but the middle cerebral artery blood flow velocity in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the disease-related indicators in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of TG, TC, and LDL-C in two groups were significantly decreased, but the levels of HDL-C in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the blood lipid levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05).Conclusion Yindan Xinnaotong Soft Capsules combined with Probucol Tablets has clinical curative effect in treatment of cerebral atherosclerosis, can improve clinical symptoms, and reduce blood lipid level, with good safety, which has a certain clinical application value.