[关键词]
[摘要]
目的 探讨金荞麦片联合头孢地尼分散片治疗急性细菌性痢疾的临床疗效。方法 选取2016年9月—2017年10月天津市宁河区医院门诊收治的110例急性细菌性痢疾患者,随机分为对照组和治疗组,每组各55例。对照组口服头孢地尼分散片,100 mg/次,2次/d。治疗组在对照组治疗的基础上口服金荞麦片,5片/次,3次/d。两组患者均连续治疗1周。观察两组患者临床疗效,比较治疗前后两组患者临床症状消失时间、不同志贺菌感染转阴情况、血清指标和不良反应发生情况。结果 治疗后,对照组和治疗组的总有效率分别为81.8%、96.4%,两组临床疗效比较差异具有统计学意义(P<0.05)。治疗后,治疗组发热、腹痛腹泻、里急后重、脓血便消失时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗组福氏志贺菌转阴率和宋氏志贺菌转阴率(90.3%、82.8%)均显著高于对照组(62.5%、61.5%)(P<0.05)。治疗后,两组血清白细胞(WBC)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、血清降钙素原(PCT)水平均较治疗前显著降低,同组比较差异具有统计学意义(P<0.05);且治疗后治疗组患者血清指标水平显著低于对照组,两组患者比较差异具有统计学意义(P<0.05)。结论 金荞麦片联合头孢地尼分散片可有效改善急性细菌性痢疾患者的腹泻、脓血便等症状,降低血清炎性指标水平,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Jinqiaomai Tablets combined with Cefdinir Dispersible Tablets in treatment of acute bacterial dysentery. Methods Patients (110 cases) with acute bacterial dysentery in Tianjin Ninghe District Hospital from September 2016 to October 2017 were randomly divided into control and treatment groups, and each group had 55 cases. Patients in the control group were po administered with Cefdinir Dispersible Tablets, 100 mg/time, twice daily. Patients in the treatment group were po administered with Jinqiaomai Tablets on the basis of the control group, 5 tablets/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, the negative situation of Shigella infection, the serum indexes, and the adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.8% and 96.4%, respectively, and there was difference between two groups (P<0.05). After treatment, the clinical symptoms disappeared times of fever, abdominal pain and diarrhea, tenesmus, and purulent stool in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). The negative conversion rates of Shigella flexneri and Shigella sonsoni in the treatment group were significantly higher than those in the control group (P<0.05). After treatment, WBC, TNF-α, CRP, and PCT levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And serum indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Jinqiaomai Tablets combined with Cefdinir Dispersible Tablets can effectively improve diarrhea, purulent stool, and other symptoms in patients with acute bacterial dysentery, and can reduce the levels of serum inflammatory indexes, which has a certain clinical application value.
[中图分类号]
[基金项目]