目的 探讨胃力康颗粒联合甲氧氯普胺片治疗反流性食管炎的临床疗效。方法 选取2014年3月—2018年3月在许昌市中心医院进行治疗的122例反流性食管炎患者作为研究对象，根据用药差别将患者分为对照组（61例）和治疗组（61例）。对照组口服甲氧氯普胺片，10 mg/次，3次/d；治疗组在对照组治疗的基础上口服胃力康颗粒，10 g/次，3次/d。两组患者均治疗4周。观察两组的临床疗效，同时比较两组治疗前后的临床症状评分、胃肠激素和血清炎症因子水平。结果 治疗后，对照组总有效率为80.33%，显著低于治疗组的96.72%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的胸骨后烧灼痛、反酸、烧心评分均明显降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组临床症状评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血浆胃泌素（GAS）、胃动素（MTL）均明显增高，血管活性肠肽（VIP）、瘦蛋白（leptin）水平均降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组胃肠激素水平显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的血清白细胞介素-6（IL-6）、白细胞介素-17（IL-17）、白细胞介素-23（IL-23）、肿瘤坏死因子-α（TNF-α）水平均明显降低，同组治疗前后比较差异具有统计学意义（P<0.05），且治疗组血清炎性因子水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 胃力康颗粒联合甲氧氯普胺片治疗反流性食管炎可有效改善临床症状，降低炎症反应，改善胃肠激素水平，具有较好的临床推广价值。

Objective To investigate the clinical efficacy of Weilikang Granules combined with Metoclopramide Tablets in treatment of reflux esophagitis. Methods Patients (122 cases) with reflux esophagitis in Xuchang Central Hospital from March 2014 to March 2018 were divided into control (61 cases) and treatment (61 cases) groups, according to the difference of medication. Patients in the control group were po administered with Metoclopramide Tablets, 10 mg/time, three times daily. Patients in the treatment group were po administered with Weilikang Granules on the basis of the control group, 10 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, gastrointestinal hormone, and serum inflammatory factor levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.33%, which was significantly lower than 96.72% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the scores of retrosternal burning pain, acid regurgitation, and heartburn in two groups were significantly decreased, and there were differences in the same group (P<0.05). And the clinical symptom scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, GAS and MTL in two groups were significantly increased, but VIP and Leptin in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, gastrointestinal hormone levels in the treatment group were significantly better than those in the control group, with difference between two groups (P<0.05). After treatment, the levels of IL-6, IL-17, IL-23, and TNF-α in two groups were significantly decreased, and there were differences in the same group (P<0.05). And the serum inflammatory factor levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Weilikang Granules combined with Metoclopramide Tablets in treatment of reflux esophagitis can effectively improve the clinical symptoms of patients, reduce the inflammatory response, and improve the gastrointestinal hormone levels, which has a certain clinical application value.