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[摘要]
目的 探讨舒筋活血胶囊联合艾瑞昔布治疗膝骨关节炎的临床疗效。方法 选取2017年5月—2018年5月在邯郸市第一医院治疗的膝骨关节炎患者88例,随机分为对照组(44例)和治疗组(44例)。对照组口服艾瑞昔布片,0.1 g/次,2次/d;治疗组在对照组基础上口服舒筋活血胶囊,1.35 g/次,3次/d。两组患者均治疗4周。观察两组患者临床疗效,同时比较治疗前后两组患者膝关节功能指标和血清学指标。结果 治疗后,对照组和治疗组临床有效率分别为81.82%和97.73%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组骨关节指数评分(WOMAC)和VAS评分均显著降低(P<0.05),膝关节功能评分(LKSS)评分显著升高(P<0.05),且治疗组WOMAC、VAS和LKSS评分明显好于对照组(P<0.05)。治疗后,两组超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、IL-17、基质金属蛋白酶-9(MMP-9)和环氧化酶-2(COX-2)水平均显著降低(P<0.05),且治疗组上述血清学指标明显低于对照组(P<0.05)。结论 舒筋活血胶囊联合艾瑞昔布片治疗膝骨关节炎,可有效降低机体炎症反应,延缓关节进一步损伤,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Shujin Huoxue Capsules combined with imrecoxib in treatment of knee osteoarthritis. Methods Patients (88 cases) with knee osteoarthritis in Handan First Hospital from May 2017 to May 2018 were randomly divided into control (44 cases) and treatment (44 cases) groups. Patients in the control group were po administered with Imrecoxib Tablets, 0.1 g/time, twice daily. Patients in the treatment group were po administered with Shujin Huoxue Capsules on the basis of the control group, 1.35 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, the knee joint function indexes and serological indexes levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 81.82% and 97.73% respectively, and there were differences between two groups (P<0.05). After treatment, the WOMAC and VAS scores in two groups were significantly decreased (P<0.05), but LKSS scores were significantly increased (P<0.05), and the WOMAC, VAS and LKSS scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the hs-CRP, IL-1β, IL-17, MMP-9, and COX-2 levels in two groups were significantly decreased (P<0.05), and these serological indexes levels in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Shujin Huoxue Capsules combined with imrecoxib in treatment of knee osteoarthritis can effectively reduce the inflammatory response and delay the further injury of the joints, which has a certain clinical application value.
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