目的 探究肾衰宁颗粒联合甘精胰岛素注射液治疗糖尿病肾病的临床疗效。方法 选取2016年2月—2017年6月天津市东丽区东丽医院收治的92例糖尿病肾病患者为研究对象，根据治疗方案将患者随机分为对照组和治疗组，每组各46例。对照组每天傍晚皮下注射甘精胰岛素注射液，初始剂量8 IU，根据患者空腹血糖水平，调整注射剂量1次/3 d，调整幅度为2 IU。治疗组在对照组治疗的基础上口服肾衰宁颗粒，1袋/次，3次/d。两组治疗时间均为8周。观察两组临床疗效，比较治疗前后两组患者的肾功能指标、血糖水平、血清炎症因子水平。结果 治疗后，对照组和治疗组的总有效率分别为71.74%、82.61%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者尿素氮（BUN）、肌酐（SCr）、24 h尿蛋白（24 h UP）水平均显著降低，肌酐清除率（CCr）水平显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组肾功能指标显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组糖化血红蛋白（HbA1c）、空腹血糖（FBG）、餐后两小时血糖（2 hPG）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）。治疗后，两组超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-8（IL-8）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）。且治疗后，治疗组血清炎性因子水平均显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 肾衰宁颗粒联合甘精胰岛素注射液治疗糖尿病肾病具有较好的临床疗效，可显著改善患者的肾功能，降低机体炎症因子，具有一定的临床推广价值。

Objective To investigate the effect of Shenshuaining Granules combined with Insulin Glargine Injection in treatment of diabetic nephropathy. Methods Patients (92 cases) with diabetic nephropathy in Dongli Hospital of Dongli District in Tianjin from February 2016 to June 2017 were randomly divided into control and treatment groups according to treatment regimen, and each group had 46 cases. Patients in the control group were sc administered with Insulin Glargine Injection at dusk, starting dosage 8 IU, adjusted dosage to once every 3 d. According to the level of patient's FBG, the adjustment range was 2 IU. Patients in the treatment group were po administered with Shenshuaining Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and the renal function indexes, blood glucose and the serum inflammatory cytokine level in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.74% and 82.61%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of BUN, Scr, and 24 h UP in two groups were significantly decreased, but CCr level was significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, the levels of BUN, Scr, 24 h UP and CCr in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of HbA1c, FBG, and 2 hPG were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the hs-CRP, TNF-α, IL-6, and IL-8 levels in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the hs-CRP, TNF-α, IL-6, and IL-8 levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Shenshuaining Granules combined with Insulin Glargine Injection has clinical curative effect in treatment of diabetic nephropathy, can significantly improve renal function, reduce inflammatory factors, which has a certain clinical application value.