目的 探讨海昆肾喜胶囊联合贝那普利治疗慢性肾小球肾炎的临床效果。方法 选取2016年6月—2018年6月天津医科大学第二医院收治的慢性肾小球肾炎患者100例，随机分成对照组（50例）和治疗组（50例）。对照组口服盐酸贝那普利片，1片/次，1次/d。治疗组在对照组基础上餐后1 h口服海昆肾喜胶囊，2粒/次，3次/d。两组均连续治疗2个月。观察两组患者临床疗效，同时比较治疗前后两组患者24 h尿蛋白定量（24 h UPQ）、尿红细胞（RBC）计数、肾功能、内皮功能和T淋巴细胞亚群水平。结果 治疗后，对照组临床总有效率为80.0%，显著低于治疗组的94.0%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组24 h UPQ、尿RBC计数及血清尿素氮（BUN）、肌酐（Cr）水平均显著下降（P<0.05），且治疗组比对照组下降更显著（P<0.05）。治疗后，两组血浆ET-1浓度较治疗前显著降低（P<0.05），一氧化氮（NO）水平显著升高（P<0.05），且治疗组患者内皮功能明显好于对照组（P<0.05）。治疗后，治疗组患者外周血CD4^＋水平和CD4^＋/CD8^＋比值均显著增加（P<0.05），CD8^＋水平则显著降低（P<0.05），且治疗组上述T淋巴细胞亚群水平明显优于对照组（P<0.05）。结论 海昆肾喜胶囊联合贝那普利治疗慢性肾小球肾炎可明显缓解患者症状，保护肾功能，改善内皮细胞功能，纠正T淋巴细胞亚群失衡。

Objective To explore the clinical effect of Haikun Shenxi Capsules combined with benazepril in treatment of chronic glomerulonephritis. Methods Patients (100 cases) with chronic glomerulonephritis in the Second Hospital of Tianjin Medical University Tianjin from June 2016 to June 2018 were randomly divided into control (50 cases) and treatment (50 cases) groups. Patients in the control group were po administered with Benazepril Hydrochloride Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Haikun Shenxi Capsules on the basis of the control group 1 h after meals, 2 grains/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacy was evaluated, and the 24 h UPQ, urinary RBC count, renal function indexes, endothelial function indexes, T lymphocyte subsets levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.0%, which was significantly lower than 94.0% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the 24 h UPQ, urinary RBC count, serum BUN and Cr levels in two groups were significantly decreased (P<0.05), and those in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the plasma ET-1 concentration in two groups was significantly decreased (P<0.05), but NO levels were significantly increased (P<0.05), and the endothelial function indexes in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the CD4⁺ levels and CD4⁺/CD8⁺ value of peripheral blood in two groups were significantly increased (P<0.05), but CD8⁺ levels were significantly decreased (P<0.05), and the T lymphocyte subsets levels in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Haikun Shenxi Capsules combined with benazepril in treatment of chronic glomerulonephritis can significantly relieve symptoms, protect renal function, improve endothelial function and correct the imbalance of T lymphocyte subsets.