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目的 探讨裸花紫珠胶囊联合硫酸阿米卡星注射液治疗尿路感染的临床疗效。方法 选取2016年6月—2018年6月在海南省万宁市人民医院治疗的尿路感染患者88例,随机分为对照组(44例)和治疗组(44例)。对照组静脉滴注硫酸阿米卡星注射液,0.2 g加入生理盐水100 mL,1次/12 h;治疗组在对照组基础上口服裸花紫珠胶囊,0.6 g/次,3次/d。两组均治疗7 d。观察两组患者临床疗效,同时比较治疗前后两组患者尿细菌清除率、临床症状评分和炎性因子水平。结果 治疗后,对照组和治疗组临床有效率分别为81.82%和97.73%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组尿细菌清除率为97.87%,相比于对照组的82.98%明显升高,两组比较差异具有统计学意义(P<0.05)。治疗后,两组尿频、尿急、尿痛症状评分均显著降低(P<0.05),且治疗组临床症状评分比对照组降低更明显(P<0.05)。治疗后,两组患者血清超敏C反应蛋白(hs-CRP)、血红素氧化酶1(HO-1)、降钙素原(PCT)、和肽素、白细胞介素-6(IL-6)水平均显著降低(P<0.05),且治疗组上述炎性因子水平明显低于对照组(P<0.05)。结论 裸花紫珠胶囊联合硫酸阿米卡星注射液治疗尿路感染可显著改善患者临床症状,降低机体炎症反应,提高尿细菌清除率。
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[Abstract]
Objective To investigate the clinical efficacy of Luohua Zizhu Capsules combined with amikacin in treatment of urinary tract infection. Methods Patients (88 cases) with urinary tract infection in People's Hospital of Wanning from June 2016 to June 2018 were randomly divided into control (44 cases) and treatment (44 cases) groups. Patients in the control group were iv administered with Amikacin Sulfate Injection, 0.2 g added into normal saline 100 mL, once every 12 h. Patients in the treatment group were po administered with Luohua Zizhu Capsules on the basis of the control group, 0.6 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the urine bacterial clearance rate, clinical symptom scores and inflammatory factors levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 81.82% and 97.73% respectively, and there were differences between two groups (P<0.05). After treatment, the urine bacterial clearance rate in the treatment group was 97.87%, which was significantly higher than 82.98% in the control group, with significant difference between two groups (P<0.05). After treatment, the frequent micturition, urgent urination and odynuria scores in two groups were significantly decreased (P<0.05), and these scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the serum hs-CRP, HO-1, PCT, copeptin, IL-6 levels in two groups were significantly decreased (P<0.05), and these inflammatory factors levels in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Luohua Zizhu Capsules combined with amikacin in treatment of urinary tract infection can significantly improve the clinical symptoms, reduce the inflammatory response and improve the bacterial clearance rate of urine.
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