目的 探讨榄香烯口服乳联合DOF方案（多西他赛＋奥沙利铂＋氟尿嘧啶）治疗晚期胃癌的临床疗效。方法 选取2017年1月—2018年3月在葫芦岛市中心医院治疗的晚期胃癌患者64例作为研究对象，采用双盲法将患者随机分为对照组和治疗组，每组各32例。对照组患者给予DOF方案治疗，即第1天静脉滴注多西他赛注射液35～40 mg/m²；后静脉滴注注射用奥沙利铂85 mg/m²，滴注2 h；第1天快速静点氟尿嘧啶注射液400 mg/m²，后续2 400 mg/m²微量泵持续输注46～48 h。治疗组在对照组治疗的基础上饭前空腹小口吞服榄香烯口服乳600 mg/d，20 mL/次，3次/d。14 d为1个周期，两组均治疗4个周期。观察两组患者的临床疗效，同时比较两组患者的生存结果和不良反应发生情况。结果 治疗后，对照组临床缓解率和疾病控制率分别为28.12%、56.25%，均显著低于治疗组的56.25%、87.50%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组中位疾病进展时间显著长于对照组，两组比较差异有统计学意义（P<0.05）。治疗期间，两组粒细胞减少、周围神经毒性、恶心呕吐、腹泻及肝功能异常发生率比较无统计学意义。结论 榄香烯口服乳联合DOF方案治疗晚期胃癌具有较好的临床疗效，能够延长患者的中位疾病进展时间，且不良反应低，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Elemene Oral Emulusion combined with DOF regimen (docetaxel+ oxaliplatin+ fluorouracil) in treatment of advanced gastric cancer. Methods Patients (64 cases) with advanced gastric cancer in Huludao Central Hospital from January 2017 to March 2018 were divided into control (32 cases) and treatment (32 cases) groups according to double-blind method. Patients in the control group were given DOF regimen. At first day, patients were iv administered with Docetaxel Injection 35-40 mg/m². And patients in the control group were iv administered with Oxaliplatin for injection 85 mg/m², dropped for 2 h. At first day, patients in the control group were iv administered with Fluorouracil Injection 400 mg/m², then continuous infusion of micropump 2 400 mg/m² for 46-48 h. Patients in the treatment group were po administered with Elemene Oral Emulusion on the basis of the control group in the morning and evening before meals, 600 mg/d. A cycle had 14 d, and patients in two groups were treated for 4 cycles. After treatment, the clinical efficacies were evaluated, survival results and adverse reactions in two groups were compared. Results After treatment, the RR and DCR in the control group were 28.12% and 56.25%, which were significantly lower than 56.25% and 87.50% in the treatment group, respectively, and there were differences between two groups (P<0.05). After treatment, the median time of disease progression in the treatment group was significantly longer than that in the control group, and there were differences between two groups (P<0.05). During the treatment, the incidence of granulocytopenia, peripheral neurotoxicity, nausea, vomiting, diarrhea and liver dysfunction in two groups were not statistically significant. Conclusion Elemene Oral Emulusion combined with DOF regimen has significant clinical effect in treatment of advanced gastric cancer, can prolong the time of median disease progression in patients, with lower adverse reactions, which has a certain clinical application value.