目的 探讨金嗓开音胶囊联合头孢拉定治疗急性喉炎患儿的有效性和安全性。方法 选取解放军第一七五医院2015年1月—2017年12月收治的急性喉炎患儿300例，随机分成对照组（150例）和治疗组（150例）。对照组患者静脉滴注注射用头孢拉定，25 mg/kg，1次/6 h；治疗组患者在对照组基础上口服金嗓开音胶囊，1粒/次，2次/d。两组患者均连续治疗7 d。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状消失时间、治愈时间、血清炎症指标和免疫因子水平及不良反应情况。结果 治疗后，对照组临床有效率为87.33%，显著低于治疗组的97.33%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者咳嗽消失时间、声音嘶哑消失时间、呼吸困难消失时间和治愈时间均显著短于对照组（P<0.05）。治疗后，两组患儿血清C反应蛋白（CRP）和白细胞介素-6（IL-6）水平显著降低（P<0.05），且治疗组患儿血清CRP和IL-6水平明显低于对照组（P<0.05）。治疗期间，对照组不良反应发生率为8.00%，显著高于治疗组的2.00%，两组比较差异具有统计学意义（P<0.05）。结论 金嗓开音胶囊联合头孢拉定治疗儿童急性喉炎疗效显著、安全性高，同时还能够改善炎症反应。

Objective To investigate the clinical efficacy and safety of Jinsang Kaiyin Capsules combined with cefradine in treatment of acute laryngitis in children. Methods Children (300 cases) with acute laryngitis in 175 Hospital of PLA from January 2015 to December 2017 were randomly divided into control (150 cases) and treatment (150 cases) groups. Children in the control group were iv administered with Cefradine for injection, 25 mg/kg, once every 6 h. Children in the treatment group were po administered with Jinsang Kaiyin Capsules on the basis of the control group, 1 grain/time, twice daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom disappearance time, healing time, serum inflammation indicators and immune factors levels, adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 87.33%, which was significantly lower than 97.33% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the disappearance time of cough, hoarseness and dyspnea, and healing time in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the serum CRP and IL-6 levels in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). During the treatment, the adverse reactions rate in the control group was 8.00%, which was significantly higher than 2.00% in the treatment group, with significant difference between two groups (P<0.05). Conclusion Jinsang Kaiyin Capsules combined with cefradine has significant curative effect in treatment of acute laryngitis in children, can also improve the inflammatory response with high safety, which has a certain clinical application value.