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[摘要]
目的 探讨银黄颗粒联合头孢丙烯片治疗急性上呼吸道感染的临床疗效。方法 选取2017年5月—2018年5月周口市中心医院治疗的94例急性上呼吸道感染患者为研究对象,根据用药的不同将患者分为对照组(47例)和治疗组(47例)。对照组口服头孢丙烯片,0.5 g/次,1次/d;治疗组在对照组治疗的基础上口服银黄颗粒,8 g/次,2次/d。两组患者均连续治疗7 d。观察两组患者的临床疗效,同时比较两组的临床症状消失时间和炎症因子水平。结果 治疗后,对照组的总有效率为80.85%,显著低于治疗组的95.74%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组的退热、咳嗽消失、咽痛消失、咽部充血消失时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清超敏C反应蛋白(hs-CRP)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和降钙素原(PCT)水平均显著下降(P<0.05);治疗后,治疗组炎症因子水平显著低于对照组(P<0.05)。结论 银黄颗粒联合头孢丙烯片治疗急性上呼吸道感染能够明显改善患者临床症状,降低机体炎症反应,具有较好的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Yinhuang Granules combined with Cefprozil Tablets in treatment of acute upper respiratory tract infection. Methods Patients (94 cases) with acute upper respiratory tract infection in Zhoukou Central Hospital from May 2017 to May 2018 were randomly divided into control (47 cases) and treatment (47 cases) groups, according to the medication. Patients in the control group were po administered with Cefprozil Tablets, 0.5 g/time, once daily. Patients in the treatment group were po administered with Yinhuang Granules on the basis of the control group, 8 g/time, twice daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, the disappearance time of clinical symptoms, and inflammatory factor levels in two groups were compared. Results After treatment, the clinical efficacy in the control group was 80.85%, which was significantly lower than 95.74% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the disappearance time of fever, cough, pharyngalgia, and pharyngeal congestion in the treatment group were shorter than those in the control group, and there were differences between two groups (P<0.05). After treatment, the levels of hs-CRP, IL-4, IL-6, TNF-α, and PCT in two groups were significantly decreased (P<0.05). After treatment, the inflammatory factor levels in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Yinhuang Granules combined with Cefprozil Tablets in treatment of acute upper respiratory tract infection can significantly improve the clinical symptoms of patients, reduce the inflammatory response, which has a certain clinical application value.
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