目的 探讨银杏酮酯滴丸联合替格瑞洛片治疗冠心病心绞痛的临床疗效。方法 选取2017年1月—2018年4月新乡医学院第一附属医院收治98例冠心病心绞痛患者作为研究对象，将所有患者随机分为对照组和治疗组，每组各49例。对照组口服替格瑞洛片，180 mg单次负荷量，之后90 mg/次，2次/d，一周后改为45 mg/次，2次/d。治疗组在对照组治疗的基础上口服银杏酮酯滴丸，8丸/次，3次/d。两组患者均持续治疗4周。观察两组患者的临床疗效和心电图疗效，比较两组治疗前后的临床症状改善情况、心肌酶谱指标和血清学指标。结果 治疗后，对照组和治疗组的总有效率分别为81.63%、91.83%，两组比较差异具有统计学意义（P<0.05）。治疗后，对照组和治疗组的心电图有效率分别为59.18%、81.63%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者心绞痛发作次数、持续时间及硝酸甘油使用量均显著下降，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组临床症状指标下降较对照组更为显著，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清肌钙蛋白T（cTnT）、肌酸激酶（CK）和同工酶（CK-MB）水平均较治疗前明显降低，同组比较差异具有统计学意义（P<0.05）；且治疗组心肌酶谱指标水平下降较对照组更显著，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清白细胞介素-18（IL-18）、脂质过氧化物（LPO）及低密度脂蛋白胆固醇（LDL-C）水平明显降低，一氧化氮（NO）水平明显增高，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组血清学指标明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 银杏酮酯滴丸联合替格瑞洛片治疗冠心病心绞痛疗效显著，可降低血清炎症因子水平和氧化应激水平，改善心肌受损情况，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Ginkgo Ketone Ester Dropping Pills combined with Ticagrelor Tablets in treatment of angina pectoris of coronary heart disease. Methods Patients (98 cases) with angina pectoris of coronary heart disease in the First Affiliated Hospital of Xinxiang Medical University from January 2017 to April 2018 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were po administered with Ticagrelor Tablets, with a single load of 180 mg, followed by 90 mg/time, twice daily, changed to 45 mg/time after 1 week, twice daily. Patients in the treatment group were po administered with Ginkgo Ketone Ester Dropping Pills, 8 pills/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy and electrocardiogram efficacy were evaluated, and the improvements of clinical symptoms, myocardial enzyme indexes, and serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.63% and 91.83%, respectively, and there was difference between two groups (P<0.05). After treatment, electrocardiogram efficacy in the control and treatment groups were 59.18% and 81.63%, respectively, and there was difference between two groups (P<0.05). After treatment, the angina attack frequency, duration, and nitroglycerin usage in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the clinical symptoms in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of cTnT, CK, and CK-MB in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the myocardial enzyme indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, IL-18, LPO, and LDL-C in two groups were significantly decreased, but NO were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, the serological indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Ginkgo Ketone Ester Dropping Pills combined with Ticagrelor Tablets has significant clinical effect in treatment of angina pectoris of coronary heart disease, can reduce the levels of serum inflammatory factors and oxidative stress, improve myocardial damage, which has a certain clinical application value.