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[摘要]
目的 探讨复方丹参滴丸联合盐酸普萘洛尔片治疗不稳定型心绞痛的临床效果。方法 选取2015年2月—2017年1月无锡市第三人民医院诊治的98例不稳定型心绞痛患者为研究对象,根据数字表法将患者随机分为对照组和治疗组,每组49例。对照组口服盐酸普萘洛尔片,10 mg/次,2次/d;治疗组在对照组的基础上口服复方丹参滴丸,10丸/次,3次/d。两组均连续用药4周。观察两组患者的临床疗效和心电图疗效,同时比较治疗前后两组患者的心绞痛发作情况、心肌酶指标。结果 治疗后,对照组和治疗组的总有效率分别为81.63%、95.92%,两组比较差异具有统计学意义(P<0.05)。治疗后,对照组和治疗组的心电图疗效总有效率分别为71.43%、89.80%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组心绞痛发作次数、发作持续时间明显降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组心绞痛发作情况明显低于对照组,两组比较差异具有统计意义(P<0.05)。治疗后,两组血清心肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组心肌酶指标水平显著低于对照组,两组比较差异具有统计意义(P<0.05)。结论 复方丹参滴丸联合盐酸普萘洛尔片治疗不稳定型心绞痛具有较好的临床疗效,可有效改善患者症状和体征,改善心肌功能,安全性高,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effects of Compound Danshen Dripping Pills combined with Propranolol Hydrochloride Tablets in treatment of unstable angina pectoris. Methods Patients (98 cases) with unstable angina pectoris in Wuxi Third People's Hospital from February 2015 to January 2017 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were po administered with Propranolol Hydrochloride Tablets, 10 mg/time, twice daily. Patients in the treatment group were po administered with Compound Danshen Dripping Pills on the basis of the control group, 3 pills/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, clinical efficacy and electrocardiogram efficacy were evaluated, and the attack of angina pectoris and myocardial enzymes indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 81.63% and 95.92%, and there were differences between two groups (P<0.05). After treatment, the efficacy of electrocardiogram in the control and treatment groups were 71.43% and 89.80%, respectively, and there was difference between two groups (P<0.05). After treatment, the frequency and duration of angina pectoris in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the attacks of angina pectoris in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of cTnI and CK-MB in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the myocardial enzymes indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Compound Danshen Dripping Pills combined with Propranolol Hydrochloride Tablets has clinical curative effect in treatment of unstable angina pectoris, can effectively improve symptoms and signs, and improve cardiac muscle function, with high safety, which has a certain clinical application value.
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