目的 观察安神补脑液联合盐酸帕罗西汀片治疗神经衰弱的临床疗效。方法 选取2016年6月—2017年6月在天津市泰达医院诊断为神经衰弱并接受规范治疗的118例患者作为研究对象，根据就诊顺序（就诊单双号）将患者分为对照组和治疗组，每组各59例。对照组早饭后口服盐酸帕罗西汀片，20 mg/次，1次/d。治疗组在对照组治疗的基础上口服安神补脑液，10 mL/次，2次/d。4周为1个疗程，两组患者共治疗3个疗程。观察两组患者的临床疗效，同时比较两组患者治疗前后的匹茨堡睡眠质量指数量表（PSQI）评分、汉密尔顿焦虑量表评分（HAMA）和汉密尔顿抑郁量表评分（HAMD）。结果 治疗后，对照组和治疗组的总有效率分别为79.66%、94.92%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者HAMA评分和HAMD评分均明显下降，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组HAMA评分和HAMD评分均明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的PSQI评分明显下降，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组PSQI评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 安神补脑液联合盐酸帕罗西汀片治疗神经衰弱能够改善患者的睡眠质量和心理情绪，安全可靠，具有一定的临床推广应用价值。

Objective To observe the clinical effect of Anshen Bunao Liquid combined with Paroxetine Hydrochloride Tablets in treatment of neurasthenia. Methods Patients (118 cases) with neurasthenia and receiving standard treatment in Tianjin TEDA Hospital from June 2016 to June 2017 were divided into control and treatment groups, according to the order of visiting (odd and even number), and each group had 59 cases. Patients in the control group were po administered with Paroxetine Hydrochloride Tablets after breakfast, 20 mg/time, once daily. Patients in the treatment group were po administered Anshen Bunao Liquid on the basis of the control group, 10 mL/time, twice daily. One course had 4 weeks, and patients in the two groups were treated for 3 courses. After treatment, the clinical efficacy was evaluated, and the scores of PSQI, HAMA, and HAMD in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.66% and 94.92%, respectively, and there was difference between two groups (P<0.05). After treatment, the HAMA and HAMD scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, HAMA and HAMD scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, PSQI scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, PSQI scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Anshen Bunao Liquid combined with Paroxetine Hydrochloride Tablets has significant curative effect in treatment of neurasthenia, can improve the sleep quality and psychological mood of patients, safe and reliable, which has a certain clinical application value.