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[摘要]
目的 探讨柏子养心丸联合枸橼酸坦度螺酮片治疗老年广泛性焦虑症的临床疗效。方法 选取2017年6月—2018年6月在青岛市城阳区人民医院治疗的老年广泛性焦虑症患者86例,根据用药的差别分为对照组(43例)和治疗组(43例)。对照组口服枸橼酸坦度螺酮片,10 mg/次,3次/d;治疗组在对照组基础上口服柏子养心丸,6 g/次,2次/d。两组患者均治疗4周。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状评分、HAMA、SAS和PSQI评分及免疫指标和神经递质水平。结果 治疗后,对照组和治疗组临床总有效率分别为79.07%和95.35%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者临床症状积分均显著降低(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,两组HAMA、SAS和PSQI量表评分均显著降低(P<0.05),且治疗组HAMA、SAS和PSQI评分明显低于对照组(P<0.05)。治疗后,两组IgG、IgA、IgM水平均显著升高(P<0.05),且治疗组IgG、IgA、IgM水平明显高于对照组(P<0.05)。治疗后,两组肾上腺素(EPH)、5-羟色胺(5-HT)和去甲肾上腺素(NE)水平均显著降低(P<0.05),且治疗组神经递质水平明显低于对照组(P<0.05)。结论 柏子养心丸联合盐酸曲唑酮片治疗老年广泛性焦虑症可有效改善患者临床症状,提高患者睡眠和生活质量,提高机体免疫能力。
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[Abstract]
Objective To investigate the clinical efficacy of Baizi Yangxin Pills combined with tandospirone citrate in treatment of senile generalized anxiety disorder. Methods Patients (86 cases) with generalized anxiety disorder in Chengyang People's Hospital from June 2017 to June 2018 were divided into control (43 cases) and treatment (43 cases) groups according to different treatments. Patients in the control group were po administered with Tandospirone Citrate Tablets, 10 mg/time, three times daily. Patients in the treatment group were po administered with Baizi Yangxin Pills on the basis of the control group, 6 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, HAMA, SAS, and PSQI scores, the immune indexes and the neurotransmitter levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 79.07% and 95.35% respectively, and there were differences between two groups (P<0.05). After treatment, the clinical symptom scores in two groups were significantly decreased (P<0.05), and clinical symptom scores in the treatment group were significantly lower than that in the control group (P<0.05). After treatment, the HAMA, SAS and PSQI scores in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the IgG, IgA, and IgM levels in two groups were significantly increased (P<0.05), and IgG, IgA, and IgM levels in the treatment group were significantly higher than those in the control group (P<0.05). After treatment, the EPH, 5-HT and NE levels in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Baizi Yangxin Pills combined with tandospirone citrate in treatment of senile generalized anxiety disorder can effectively improve the clinical symptoms, the sleep and life quality and the immune ability.
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