目的 探讨脑心通胶囊联合单唾液酸四己糖神经节苷脂钠注射液治疗急性脑梗死的临床疗效。方法 选取2016年4月—2017年12月在荆门市中医医院接受治疗的急性脑梗死患者128例为研究对象，将所有患者根据随机数字表法分为对照组和治疗组，每组各64例。对照组静脉滴注单唾液酸四己糖神经节苷脂钠注射液，40 mg加入到0.9%氯化钠溶液250 mL中，1次/d；治疗组在对照组治疗的基础上口服脑心通胶囊，4粒/次，3次/d。两组患者均连续治疗2周。观察两组的临床疗效，比较两组的NIHSS评分、血液流变学指标和血清学指标同型半胱氨酸（Hcy）、超敏C反应蛋白（hs-CRP）、S100β蛋白、血管内皮生长因子（VEGF）水平。结果 治疗后，对照组和治疗组的总有效率分别为75.00%、90.63%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者NIHSS评分均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组NIHSS评分明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者全血高切黏度、全血低切黏度、HCT、FIB和红细胞聚集指数均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组血液流变学指标显著低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者血清Hcy、hs-CRP、S100β蛋白水平均明显降低，VEGF水平明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组上述指标明显优于对照组，两组比较差异有统计学意义（P<0.05）。结论 脑心通胶囊联合单唾液酸四己糖神经节苷脂钠注射液治疗急性脑梗死的疗效显著，可改善血液流变学指标，减轻炎症反应，抑制血栓形成，促进患者神经功能的恢复，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of Naoxintong Capsules combined with Monosialotetrahexosylganglioside Sodium Injection in treatment of acute cerebral infarction. Methods Patients (128 cases) with acute cerebral infarction in Jingmen Traditional Chinese Medicine Hospital from April 2016 to February 2017 were randomly divided into control and treatment groups, and each group had 64 cases. Patients in the control group were iv administered with Monosialotetrahexosylganglioside Sodium Injection, 40 mg added into normal saline 250 mL, once daily. Patients in the treatment group were po administered with Naoxintong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and NIHSS scores, blood rheology indexes and serological indicators, such as Hcy, hs-CRP, s100β, and VEGF in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 75.00% and 90.63%, respectively, and there was difference between two groups (P<0.05). After treatment, NIHSS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the NIHSS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, whole blood viscosity, plasma viscosity, HCT, FIB, and erythrocyte aggregation index in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of Hcy, hs-CRP, and s100β in two groups were significantly decreased, but the levels of VEGF in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Naoxintong Capsules combined with Monosialotetrahexosylganglioside Sodium Injection has clinical curative effect in treatment of acute cerebral infarction, can improve the blood rheology index, reduce inflammation, inhibit thrombosis, and promote the recovery of nerve function in patients, which has a certain clinical application value.