随着肺癌相关基因组学研究的深入及高通量测序技术的发展，越来越多的驱动基因在肺癌中被发现，这为肺癌的精准治疗提供了一种新途径。对近年来肺癌的靶向药物的作用机制及其耐药机制的研究进展进行综述，旨在帮助读者对肺癌靶向药物的个体化选择及耐药机制有一个全面的了解。

With the development of lung cancer-related genomics research and the development of high-throughput sequencing technology, more and more driving genes are found in lung cancer, which provides a new way for the precise treatment of lung. Research progress on action mechanism of and drug resistance mechanism of molecular targeted drugs for lung cancer are reviewed in this paper, aiming to help readers have a comprehensive understanding of the individualized choice of lung cancer targeted drugs.

重庆医科大学附属永川医院青年课题（YJQN2011032）