目的 了解2017年天津医科大学代谢病医院门诊降糖药物的使用情况，为临床合理用药提供依据。方法 采用WHO推荐的限定日剂量（DDD）法对2017年天津医科大学代谢病医院治疗糖尿病药物的种类、规格、销量、销售金额、用药频度（DDDs）、日均费用（DDC））和排序比（B/A）等进行统计分析。结果 胰岛素注射液的销售金额及构成比在各类降糖药物中一直位居第1位，口服降糖药中α-葡萄糖苷酶抑制剂的销售金额远超其他5类口服降糖药，占比27.50%。双胍类药物的年销售数量居首位，其中盐酸二甲双胍片的销量稳居第1位，门冬胰岛素30注射液的销量在众多胰岛素中排名第1位。DDDs排序前5名的药品为阿卡波糖片、格列美脲片、瑞格列奈片、门冬胰岛素30、盐酸二甲双胍片。胰岛素注射液类降糖药的DDC普遍高于其他口服降糖药。双胍类的B/A均高于1.00，α-葡萄糖苷酶抑制剂的B/A均低于1.00。结论 临床应选择适合的降糖药物来控制糖尿病患者的血糖，提高患者的依从性，降低患者的经济负担，促进临床合理用药。

Objective To investigate the use of anti-diabetic drugs in Metabolic Disease Hospital of Tianjin Medical University in 2017, and to provide reference for reasonable application of anti-diabetic drugs. Methods The applied category, specifications, sales volume, consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) of anti-diabetic drugs in Metabolic Disease Hospital of Tianjin Medical University in 2017 were analyzed statistically according to the WHO-recommended DDD (defined daily dose) method. Results Consumption sum and constituent ratio of Insulin Injection in various anti-diabetic drugs had always been the first. Consumption sum of α-glucosidase inhibitors in oral anti-diabetic drugs was far more than the other 5 types of oral hypoglycemic drugs, accounting for 27.50%. Annual sales volume of biguanides ranked the first, in which sales of Metformin Hydrochloride Tablets was at the first place. Sales of Insulin Aspart 30 Injection in all insulins ranked the first. Anti-diabetic drugs with top five DDDs were Acarbose Tablets, Glimepiride Tablets, Repaglinide Tablets, Insulin Aspart 30 Injection, and Metformin Hydrochloride Tablets. DDC of Insulin Injection was higher than that of other oral hypoglycemic drugs. B/A of biguanides was higher than 1.00, while B/A of α-glucosidase inhibitors was lower than 1.00. Conclusion The clinic should select a suitable anti-diabetic drug to control the blood glucose of the diabetic patients, improve the patient's compliance, reduce the economic burden of the patients, and promote rational drug use in the clinic.