目的 探讨独一味胶囊联合甲硝唑治疗慢性牙龈炎的临床效果。方法 选取北京怀柔医院2016年2月—2017年10月收治的慢性牙龈炎患者112例，随机分成对照组和治疗组，每组各56例。对照组患者将甲硝唑口颊片置于牙龈与龈沟处含化，1片/次，3次/d。治疗组在对照组的基础上口服独一味胶囊，3粒/次，3次/d。两组患者连续治疗14 d。观察两组患者临床疗效，同时比较治疗前后两组患者龈沟出血指数（SBI）、菌斑指数（PLI）、龈沟液肿瘤坏死因子-α（TNF-α）水平。结果 治疗后，对照组和治疗组临床有效率分别为80.36%和94.64%，两组比较差异具有统计学意义（P<0.05）。治疗7、14 d后，两组患者SBI、PLI指数和龈沟液TNF-α水平均比治疗前显著降低，同组比较差异具有统计学意义（P<0.05）；且治疗组治疗7、14 d后SBI、PLI指数和龈沟液TNF-α水平比同时期对照组均明显降低，两组比较差异具有统计学意义（P<0.05）。结论 独一味胶囊联合甲硝唑治疗慢性牙龈炎疗效显著，且无明显不良反应，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Duyiwei Capsules combined with metronidazole in treatment of chronic gingivitis. Methods Patients (112 cases) with chronic gingivitis in Beijing Huairou Hospital from February 2016 to October 2017 were randomly divided into control and treatment groups, and each had 56 cases. Patients in the control group were buccally administered with Metronidazole Buccal Tablets in gingiva and gingival sulcus, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Duyiwei Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the SBI, PLI indexes, and TNF-α levels in gingival crevicular fluid in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.36% and 94.64% respectively, and there were differences between two groups (P<0.05). After treatment for 7, 14 d, the SBI, PLI indexes and TNF-α levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment for 7, 14 d, the SBI, PLI indexes and TNF-α levels in the treatment group were significantly lower than those in the control group of the same period, with significant difference between two groups (P<0.05). Conclusion Duyiwei Capsules combined with metronidazole in treatment of chronic gingivitis has obvious curative effect without obvious adverse reaction, which has a certain clinical application value.