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[摘要]
目的 探讨少腹逐瘀颗粒联合醋酸甲羟孕酮片治疗子宫内膜异位症的临床效果。方法 选取2015年2月—2016年6月绵阳市中心医院收治的子宫内膜异位症患者98例作为研究对象,所有患者随机分为对照组和治疗组,每组各49例。对照组患者口服醋酸甲羟孕酮片,1片/次,1次/d。治疗组在对照组治疗的基础上口服少腹逐瘀颗粒,1袋/次,3次/d。两组均连续治疗6个月。评估两组患者的临床疗效,同时比较两组患者的盆腔包块大小、VAS评分、糖类抗原125(CA125)、雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)、超敏C反应蛋白(hs-CRP)白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、复发率和痛觉发生情况。结果 治疗后,治疗组的总有效率为93.9%,显著高于对照组的73.5%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者盆腔包块大小、VAS评分和CA125均较治疗前均显著下降,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组盆腔包块大小、VAS评分和CA125显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者E2水平较治疗前均显著下降,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组E2水平明显低于对照组,两组间比较差异具有统计学意义(P<0.05)。治疗后,两组患者hs-CRP、IL-6和TNF-α水平较治疗前均显著下降,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组炎症指标水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。随访1年后,治疗组患者复发率明显低于对照组(P<0.05),且痛觉人数明显少于对照组(P<0.05)。结论 少腹逐瘀颗粒联合醋酸甲羟孕酮片治疗子宫内膜异位症具有较好的临床疗效,有助于缓解患者临床症状、降低机体炎症反应、降低复发率,且安全性高,具有一定的临床推广价值。
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[Abstract]
Objective To investigate the clinical effect of Shaofu Zhuyu Granules combined with Medroxyprogesterone Acetate Tablets in treatment of endometriosis. Methods Patients (98 cases) with endometriosis in Mianyang Central Hospital from February 2015 to June 2016 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were po administered with Medroxyprogesterone Acetate Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Shaofu Zhuyu Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 6 month. After treatment, the clinical efficacies were evaluated, and the pelvic mass size, VAS, CA125, E2, FSH, LH, hs-CRP, IL-6, TNF-α, recurrence rate, and the occurrence of pain in two groups were compared. Results After treatment, the clinical efficacy in the treatment group was 93.9%, which was significantly higher than 73.5% in the control group, and there were differences between two groups (P<0.05). After treatment, the pelvic mass size, VAS, and CA125 in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the pelvic mass size, VAS scores, and CA125 levels in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, the E2 level in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the E2 levels in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, the levels of hs-CRP, IL-6, and TNF-α in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the serum Inflammatory index levels in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After 1 year of follow-up, the recurrence rate in the treatment group was significantly lower than that in the control group (P<0.05), and the numbers of pain was significantly less than that in the control group (P<0.05). Conclusion Shaofu Zhuyu Granules combined with Medroxyprogesterone Acetate Tablets has significant clinical effect in treatment of endometriosis, can alleviate the clinical symptoms of patients, reduce inflammation reaction, and reduce recurrence rate, with high safety, which has a certain clinical application value.
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