目的 探讨葆宫止血颗粒联合甲羟孕酮治疗药物流产后持续阴道出血的临床疗效。方法 选取2017年1月—2018年6月新乡医学院第一附属医院收治的122例药物流产后持续阴道出血患者，随机分为对照组和治疗组，每组各61例。对照组口服醋酸甲羟孕酮片，10 mg/次，1次/d。治疗组在对照组治疗基础上口服葆宫止血颗粒，1袋/次，3次/d。两组均治疗7 d。观察两组的临床疗效，比较两组出血控制、月经恢复、宫腔组织残留情况。比较两组治疗前后子宫内膜厚度、孕酮（P）、人绒毛膜促性腺激素（HCG）的变化情况。结果 治疗后，对照组和治疗组的总有效率分别是83.6%、95.1%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组阴道出血持续时间、月经复潮时间均显著短于对照组，且治疗组阴道出血量、月经复潮量均少于对照组，两组比较差异具有统计学意义（P<0.05）。治疗组宫内组织残留率为8.2%显著低于对照组21.3%，两组比较差异具有统计学意义（P<0.05）；治疗后，两组子宫内膜厚度均显著增加，血清P、HCG水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组子宫内膜厚度显著高于对照组，治疗组血清P、HCG水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，对照组和治疗组的并发症发生率分别是19.7%、6.6%，两组比较差异具有统计学意义（P<0.05）。结论 葆宫止血颗粒联合甲羟孕酮治疗药物流产后持续阴道出血具有较好的临床疗效，能有效控制出血，促进子宫内膜修复及宫内残留组织的排出，减少并发症，促进月经复潮，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Baogong Zhixue Granules combined with medroxyprogesterone in treatment of persistent vaginal bleeding after drug abortion. Methods 122 Patients with persistent vaginal bleeding after drug abortion in the First Affiliated Hospital of Xinxiang Medical University from January 2017 to June 2018 were randomly divided into control (61 cases) and treatment (61 cases) groups. Patients in the control group were po administered with Medroxyprogesterone Acetate Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Baogong Zhixue Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the situations of bleeding, menstrual recovery, uterine cavity tissue residue in two groups were compared. The changes of endometrial thickness, progesterone (P) and human chorionic gonadotropin (HCG) before and after treatment in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment group were 83.6% and 95.1%, and there were differences between two groups (P<0.05). After treatment, the duration of vaginal bleeding and menstrual rehydration in the treatment group were significantly shorter than those in the control group, and the amount of vaginal bleeding and menstrual rehydration in the treatment group was less than that in the control group, and there were differences between two groups (P<0.05).The intrauterine tissue residual rate of the treatment group was 8.2%, which was significantly lower than that of the control group (21.3%), and there were differences between two groups (P<0.05). After treatment, endometrium thickness in two groups was significantly increased, but P and HCG were significantly decreased, and there were differences in the same group (P<0.05). After treatment, endometrium thickness in the treatment group was significantly higher than that of the control group, but P and HCG were significantly lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, the complication rate in the control and treatment group was 19.7% and 6.6%, and there were differences between two groups (P<0.05).Conclusion Baogong Zhixue Granules combined with medroxyprogesterone has significant clinical effect in treatment of persistent vaginal bleeding after drug abortion, and can effectively control bleeding, also can promote endometrial repair and discharge of intrauterine residual tissue, and reduce complications, and promote menstruation, which has a certain clinical application value.