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[摘要]
目的 探讨妇炎康胶囊联合阴道用乳杆菌活菌胶囊治疗细菌性阴道病的临床效果。方法 选取2017年3月—2018年3月在吉林医药学院附属医院诊治的细菌性阴道病患者155例,随机分成对照组(77例)和治疗组(78例)。对照组患者每晚清洁外阴后阴道深部放入阴道用乳杆菌活菌胶囊,1粒/次;治疗组患者在对照组基础上口服妇炎康胶囊,6粒/次,3次/d。两组患者均连续治疗20 d。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状消失时间、阴道清洁度、改良胺试验和线索细胞转阴率。结果 治疗后,对照组和治疗组临床有效率分别为84.42%和96.15%,两组比较差异具有统计学意义(P<0.05)。治疗组患者白带增多消失时间、外阴瘙痒消失时间及阴道异味消失时间均显著早于对照组患者,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者的阴道清洁度Ⅰ~Ⅱ度例数显著多于对照组患者,改良胺试验及线索细胞转阴率显著高于对照组患者,两组比较差异具有统计学意义(P<0.05)。结论 妇炎康胶囊联合阴道用乳杆菌活菌治疗细菌性阴道病疗效显著,临床症状消失时间短,安全性好,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Fuyankang Capsules combined with Live Lactobacillus Capsule for Vaginal Use in treatment of bacterial vaginosis. Methods Patients (155 cases) with bacterial vaginosis in Affiliated Hospital of Jilin Medical University from March 2017 to March 2018 were randomly divided into control (77 cases) and treatment (78 cases) groups. Patients in the control group were vagina near the deep administered with Live Lactobacillus Capsule for vaginal use after cleaning the vulva every night, 1 grain/time. Patients in the treatment group were po administered with Fuyankang Capsules on the basis of the control group, 6 grains/time, three times daily. Patients in two groups were treated for 20 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, vaginal cleaning degree, ameliorated-Whiff test and negative rate of clue cells in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the control and treatment groups was 84.42% and 96.15% respectively, and there were differences between two groups (P<0.05). After treatment, the disappearance time of leukorrhagia, pruritus vulvae and vaginal odor in the treatment group was significantly earlier than that in the control group, with significant difference between two groups (P<0.05). After treatment, the cases of vaginal cleaningⅠ - Ⅱ degree in the treatment group were significantly more than patients in the control group, ameliorated-Whiff test and negative rate of clue cells in the treatment group was significantly higher than that in the control group, with significant difference between two groups (P<0.05). Conclusion Fuyankang Capsules combined with Live Lactobacillus Capsule for vaginal use has significant curative effect in treatment of bacterial vaginosis with high safty, and the disappearance time of clinical symptoms is earlier, which has a certain clinical application value.
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