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[摘要]
目的 研究参芎葡萄糖注射液联合厄贝沙坦片治疗糖尿病肾病的临床疗效。方法 选取2015年3月—2017年3月海南省第三人民医院接收的120例糖尿病肾病患者作为研究对象,随机将所有患者分为对照组和治疗组,每组各60例。对照组患者口服厄贝沙坦片75 mg/次,2次/d;治疗组在对照组治疗的基础上静脉滴注参芎葡萄糖注射液,200 mL/次,1次/d。两组患者均持续治疗30 d。观察两组患者临床疗效,比较两组患者在治疗前后的空腹血糖(FBG)、糖化血红蛋白(HbAlc)、尿白蛋白排泄率(UAER)、尿α1微球蛋白(α1-MG)、血清肌酐(Scr)、尿素氮(BUN)、尿酸(UA)水平。结果 治疗后,对照组和治疗组的总有效率分别为88.33%、96.67%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者FBG和HbAlc水平均比治疗前显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组患者血糖指标水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者的UAER和α1-MG水平均显著下降,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组UAER和α1-MG水平均明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者UA和治疗前相比显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组UA显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 参芎葡萄糖注射液联合厄贝沙坦片治疗早期糖尿病肾病具有较好的临床疗效,改善血糖和肾功能指标,具有一定的临床推广应用价值。
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[Abstract]
Objective To study the clinical effect of Salivae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection combined with Irbesartan Tablets in treatment of diabetic nephropathy. Methods Patients (120 cases) with diabetic nephropathy in the Third People's Hospital of Hainan Province from March 2015 to March 2017 were randomly divided into control group and treatment group, and each group had 60 cases. Patients in the control group were po administered with Irbesartan Tablets, 75 mg/time, twice daily. Patients in the treatment group were iv administered with Salivae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection on the basis of the control group, 200 mL/time, once daily. Patients in two groups were treated for 30 d. After treatment, the clinical efficacy was evaluated, and the levels FBG, HbAlc, UAER, α1-MG, Scr, BUN, and UA in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 88.33% and 96.67%, respectively, and there were differences between two groups (P<0.05). After treatment, FBG and HbAlc levels were significantly decreased in two groups, and there were differences in the same group (P<0.05). After treatment, the blood glucose indexes in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment,UAER and α1-MG levels were significantly decreased in two groups, and there were differences in the same group (P<0.05). After treatment, UAER and α1-MG levels in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, UA level were significantly decreased in two groups, and there were differences in the same group (P<0.05). After treatment, UA level in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). Conclusion Salivae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection combined with Irbesartan Tablets has significant clinical efficacy in treatment of diabetic nephropathy, can improve blood sugar and renal function, which has a certain clinical application value.
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