目的 探讨达立通颗粒联合法莫替丁治疗胃食管反流病的临床疗效。方法 选取2017年5月—2018年5月在洪湖市中医医院治疗的胃食管反流病患者82例，根据用药差别分为对照组（41例）和治疗组（41例）。对照组口服法莫替丁片，20 mg/次，2次/d；治疗组在对照组基础上口服达立通颗粒，6 g/次，3次/d。两组均治疗8周。观察两组患者临床疗效，同时比较治疗前后两组患者GerdQ评分、SF-36评分、食管测压和24 h食管pH监测情况。结果 治疗后，对照组临床有效率为80.49%，显著低于治疗组的97.56%，两组比较差异具有统计学意义。治疗后，两组GerdQ评分显著降低（P<0.05），SF-36评分显著升高（P<0.05），且治疗组GerdQ和SF-36评分明显好于对照组（P<0.05）。治疗后，两组上食管括约肌（UES）静息压、下食管括约肌（LES）静息压、蠕动波传导速度、湿咽成功率明显升高（P<0.05），且治疗组上述食管测压指标明显高于对照组（P<0.05）。治疗后，两组24 h食管酸反流总次数、酸反流大于5 min次数、总计pH<4百分比、最长反流时间均显著降低（P<0.05），且治疗组这些指标明显低于对照组（P<0.05）。结论 达立通颗粒联合法莫替丁治疗胃食管反流病可有效改善患者临床症状，有利于食管动力改善，降低酸反流，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Dalitong Granules combined with famotidine in treatment of gastroesophageal reflux disease. Methods Patients (82 cases) with gastroesophageal reflux disease in Honghu Hospital of Traditional Chinese Medicine from May 2017 to May 2018 were divided into control (41 cases) and treatment (41 cases) groups based on different treatments. Patients in the control group were po administered with Famotidine Tablets, 20 mg/time, twice daily. Patients in the treatment group were po administered with Dalitong Granules on the basis of the control group, 6 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and GerdQ scores, SF-36 scores, esophageal manometry and 24 h esophageal pH monitoring in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.49%, which was significantly lower than 97.56% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the GerdQ scores in two groups were significantly decreased (P<0.05), but SF-36 scores were significantly increased (P<0.05), and the GerdQ and SF-36 scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the resting pressure of UES and LES, creeping wave conduction velocity, and success rate of wet pharynx in two groups was significantly increased (P<0.05), and the esophageal manometry in the treatment group were significantly higher than that in the control group (P<0.05). After treatment, the total frequency of 24 h esophageal acid reflux, the frequency of acid reflux time >5 min, total pH<4 ratio, and maximum acid reflux time in two groups was significantly decreased (P<0.05), and these indexes in the treatment group were significantly lower than that in the control group (P<0.05). Conclusion Dalitong Granules combined with famotidine in treatment of gastroesophageal reflux disease can effectively improve the clinical symptoms and the esophageal motility, reduce acid reflux, which has a certain clinical application value.