目的 对2017年天津市人民医院住院患者特殊使用级抗菌药物的使用情况进行回顾性分析，为特殊使用级抗菌药物的合理性应用管理提供参考依据。方法 回顾性分析2017年1～12月天津市人民医院住院患者应用特殊使用级抗菌药物的临床资料，从患者性别、年龄、科室分布、用药频度（DDDs）、金额、药物利用指数（DUI）等进行分析，并进行用药合理性分析。结果 2017年特殊使用级抗菌药物患者男女比为1.28∶1，无性别差异；年龄分布以>60岁患者为主，使用率≥5%的临床科室分别为重症医学科、呼吸科、急诊科、普外科、老年病科、感染免疫科、肛肠科，使用率分别为30.9%、16.3%、15.1%、9.9%、7.0%、5.2%、5.0%；患者临床标本送检率为85.7%～100.0%，平均送检率为92.8%；比阿培南的使用频次最高，为890次，占42.02%。DDDs排首位的是比阿培南，末位是卡泊芬净，特殊使用级抗菌药物以单药为主，联合用药率为9.7%，主要以两种联用为主。结论 2017年天津市人民医院住院患者特殊使用级抗菌药物的使用基本合理，但存在一些问题，需要进一步加强监督和管理。

Objective To analyze the application of special class antibiotic drugs in inpatients of Tianjin Union Medical Center in 2017, in order to provide reference for detailed management of special class antibiotic drugs. Methods A retrospective study was conducted on the application data of special class antibiotic drugs in inpatients Tianjin Union Medical Center in 2017. The basic condition, distribution of clinical department, frequency of durg use (DDDs), consumption sums, and DUI were recorded and analyzed, and the rationality of using antibiotics was evaluated. Results Patients The ratio of male and female using special class antibiotic drugs was 1.28:1, and there was no difference between gender. The majority of patients were over 60 years old. The clinical departments with the usage rate above 5% were Department of Critical Care Medicine, Department of Respiratory, Department of Emergency, Department of General Surgery, Department of Geriatrics, Department of Infectious Immunology, and Department of Proctology, accounting for 30.9%, 16.3%, 15.1%, 9.9%, 7.0%, 5.2%, and 5.0%. The delivery rates of different departments were 85.7%-100.0%, in average 92.8%.The frequency of usage of biapenem (890 cases) was highest, accounting for 42.02%. DDDs of biapenem ranked the first, while DDDs of caspofungin ranked the last. Single agent therapy was common, while the rate of combination therapy was 9.7%, mainly double combination. Conclusion The application of special class antibiotic drugs in inpatients of Tianjin Union Medical Center in 2017 is basically reasonable, but there are still several problems, and supervision and management need to be further strengthened.