目的 观察蚕茸柱天胶囊联合西地那非治疗勃起功能障碍的有效性与安全性。方法 选择2015年6月—2017年6月在延安市人民医院治疗的勃起功能障碍患者120例，随机分成对照组和治疗组，每组各60例。对照组患者性交前30 min口服枸橼酸西地那非片，初始剂量为50 mg/次，1次/d，每周至少1次但不超过4次，剂量25～100 mg。治疗组患者在对照组基础上口服蚕茸柱天胶囊，2粒/次，2次/d。两组患者均连续治疗3个月。观察两组患者临床疗效，同时比较治疗前后两组患者阴茎勃起硬度、国际勃起功能-5（ⅡEF-5）和勃起质量量表（QEQ）评分及不良反应情况。结果 治疗后，对照组和治疗组临床有效率分别为80.00%、95.00%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者阴茎勃起硬度Ⅰ级和Ⅱ级患者人数显著少于对照组（P<0.05），且阴茎勃起硬度Ⅲ级和Ⅳ级患者人数显著多于对照组（P<0.05）。治疗后，两组患者ⅡEF-5和QEQ评分均显著升高（P<0.05），且治疗组患者ⅡEF-5和QEQ评分比对照组升高的更明显（P<0.05）。治疗期间，治疗组不良反应发生率为5.00%，明显低于对照组的20.00%，两组比较差异具有统计学意义（P<0.05）。结论 蚕茸柱天胶囊联合西地那非治疗勃起功能障碍具有疗效好、副作用低，同时能够改善患者的生活质量，具有一定的临床推广应用价值。

Objective To observe the clinical efficacy and safety of Canrong Zhutian Capsules combined with sildenafil in treatment of erectile dysfunction. Methods Patients (120 cases) with erectile dysfunction in Yan'an People's Hospital from June 2015 to June 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Sildenafil Citrate Tablets 30 min before sexual intercourse, and the initial dose was 50 mg/time, once daily, and at least once a week but not more than 4 times, the dose was 25-100 mg. Patients in the treatment group were po administered with Canrong Zhutian Capsules on the basis of the control group, 2 grains/time, twice daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the penile erection hardness, ⅡEF-5 and QEQ scores, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.00% and 95.00%, respectively, and there were differences between two groups (P<0.05). After treatment, persons of Ⅰ and Ⅱ grade of penile erection hardness in the treatment group were significantly less than those in the control group (P<0.05), and persons of Ⅲ and Ⅳ grade of penile erection hardness in the treatment group were significantly more than those in the control group (P<0.05). After treatment, the ⅡEF-5 and QEQ scores in two groups was significantly increased (P<0.05), and these scores in the treatment group were significantly higher than those in the control group (P<0.05). During the treatment, the adverse reactions rate in the treatment group was 5.00%, which was significantly lower than 20.00% in the control group, with significant difference between two groups (P<0.05). Conclusion Canrong Zhutian Capsules combined with sildenafil has a good curative effect in treatment of erectile dysfunction with less side adverse reactions, can improve the quality of life, which has a certain clinical application value.