目的 探讨肿痛安胶囊联合替硝唑片治疗牙周炎的临床疗效。方法 选取2017年3月—2018年2月在凉山彝族自治州第一人民医院就诊的牙周炎患者94例为研究对象，将所有患者按照随机数字表法分为对照组和治疗组，每组各47例。对照组给予替硝唑片，1.0 g研磨后与适量蒸馏水混合，制作成10%的替硝唑蒸馏水混悬液，采用明胶海绵浸药后置入病变牙周袋，隔日1次。治疗组在对照组治疗的基础上口服肿痛安胶囊，2粒/次，3次/d。两组患者均连续治疗2周。观察两组的临床疗效，比较两组的牙周指标和龈沟液细胞因子水平。结果 治疗后，对照组和治疗组的总有效率分别为70.21%、89.36%，两组比较差异有统计学意义（P<0.05）。治疗后，两组菌斑指数、牙周袋探诊深度、龈沟出血指数、牙周附着水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组牙周指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组超敏C反应蛋白（hs-CRP）、基质金属蛋白酶8（MMP-8）、基质金属蛋白抑制酶1（TIMP-1）、前列腺素E₂（PGE₂）水平明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组龈沟液细胞因子水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 肿痛安胶囊联合替硝唑片治疗牙周炎具有较好的临床疗效，可改善牙周指标，减轻牙周炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Zhongtong'an Capsules combined with Tinidazole Tablets in treatment of periodontitis. Methods Patients (94 cases) with periodontitis in the First People's Hospital of Yi Autonomous Prefecture of Liangshan from March 2017 to February 2018 were randomly divided into control and treatment groups, and each group had 47 cases. Patients in the control group were given Tinidazole Tablets, 1.0 g was mixed with distilled water to make 10% tinidazole distilled water suspension, then the mixed liquid was applied to the periodontal pocket, once every other day. Patients in the treatment group were po administered with Zhongtong'an Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and periodontal indexes and the levels of cytokines in gingival crevicular fluid in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 70.21% and 89.36%, respectively, and there was difference between two groups (P<0.05). After treatment, plaque index, probing depth of periodontal pocket, gingival crevicular bleeding index, and periodontal attachment level in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the periodontal indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of hs-CRP, MMP-8, TIMP-1, and PGE₂ in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the levels of cytokines in gingival crevicular fluid in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Zhongtong'an Capsules combined with Tinidazole Tablets has clinical curative effect in treatment of periodontitis, can improve periodontal index, and reduce periodontal inflammation, which has a certain clinical application value.