目的 研究注射用胸腺法新联合注射用头孢哌酮钠舒巴坦钠治疗肝硬化合并自发性细菌性腹膜炎的临床疗效。方法 选取2015年10月—2017年10月凉山彝族自治州第一人民医院收治的88例肝硬化合并自发性细菌性腹膜炎患者作为研究对象，将所有患者随机分为对照组和治疗组，每组各44例。对照组静脉滴注注射用头孢哌酮钠舒巴坦钠，2 g溶于100 mL氯化钠溶液中，2次/d。治疗组在对照组治疗的基础上皮下注射注射用胸腺法新，1次/3 d。两组患者均持续治疗2周。观察两组临床疗效，同时比较两组治疗前后的体征变化时间、腹水指标变化情况和免疫功能指标。结果 治疗后，对照组和治疗组的总有效率分别为81.8%、93.2%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组体温复常时间、腹水消失时间、腹水常规正常时间、腹水培养阴性时间和腹部压痛消失时间均显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的降钙素原（PCT）、白细胞介素-6（IL-6）和肿瘤坏死因子（TNF-α）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组的腹水指标水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的CD3⁺、CD4⁺、CD4⁺/CD8⁺和NK细胞均有所改善，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组免疫功能改善更为明显，两组比较差异具有统计学意义（P<0.05）。结论 注射用胸腺法新联合注射用头孢哌酮钠舒巴坦钠治疗肝硬化自发性细菌性腹膜炎疗效显著，可有效减轻患者炎症反应，提升机体免疫能力，具有一定的临床推广使用价值。

Objective To investigate the clinical efficacy of Thymalfasin for injection combined with Cefoperazone Sodium and Sulbactam Sodium for injection in treatment of liver cirrhosis with spontaneous bacterial peritonitis. Methods Patients (88 cases) with liver cirrhosis with spontaneous bacterial peritonitis in the First People's Hospital of Liangshan Yi Autonomous Prefecture from October 2015 to October 2017 were randomly divided into control and treatment groups, and each group had 44 cases. Patients in the control group were iv administered with Cefoperazone Sodium and Sulbactam Sodium for injection, 2 g added into sodium chloride solution 100 mL, twice daily. Patients in the treatment group were sc administered with Thymalfasin for injection on the basis of the control group, once every three days. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the change time of signs, the changes of ascites indexes, and the immune function indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 81.8% and 93.2%, and there were differences between two groups (P<0.05). After treatment, the recovery time of body temperature, the disappearance time of ascites, the routine normal time of ascites, the negative time of ascites culture and the disappearance time of abdominal tenderness in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P<0.05). After treatment, levels of PCT, IL-6, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, and the ascites index levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺, and NK cells in the two groups were significantly improved, and the difference was statistically significant in the same group (P<0.05). After treatment, the immune function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Thymalfasin for injection combined with Cefoperazone Sodium and Sulbactam Sodium for injection has significant curative effect in treatment of liver cirrhosis with spontaneous bacterial peritonitis, can effectively reduce the inflammation reaction of patients, and improve the immunity of the body, which has a certain clinical application value.