目的 研究固肾定喘丸联合吸入用布地奈德混悬液治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法 选取2015年6月—2017年6月麻城市人民医院接收的120例慢性阻塞性肺疾病急性加重期患者作为研究对象，将所有患者随机分为对照组和治疗组，每组各60例。对照组雾化吸入用布地奈德混悬液，1支/次，2次/d；治疗组患者在对照组治疗的基础上口服固肾定喘丸，3 g/次，3次/d。两组患者均持续治疗14 d。观察两组患者的临床疗效，比较两组治疗前后的临床症状消失时间、肺功能指标和血清炎性因子水平。结果 治疗后，治疗组的总有效率为95.00%，显著高于对照组的85.00%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者喘息、哮鸣音、咳嗽消失时间显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者秒用力呼气容积（FEV₁）、用力肺活量（FVC）和FEV₁/FVC水平均显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组肺功能指标显著高于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组血清炎性因子水平显著低于对照组，两组比较差异有统计学意义（P<0.05）。结论 固肾定喘丸联合吸入用布地奈德混悬液治疗慢性阻塞性肺疾病急性加重期具有较好的临床疗效，能够改善患者临床症状、肺功能和血清炎性因子水平，安全性较高，值得临床推广。

Objective To study the clinical effect of Gushen Dingchuan Pills combined with Budesonide Suspension for inhalation in treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods Patients (120 cases) with acute exacerbation of chronic obstructive pulmonary disease in Macheng People's Hospital from June 2015 to June 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were atomization inhalation administered with Budesonide Suspension for inhalation, 1 tube/time, twice daily. Patients in the treatment group were po administered with Gushen Dingchuan Pills on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, lung function indexes, and the serum inflammatory factors levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the treatment group was 95.00%, which was significantly higher than 85.00% in control the group, and there were differences between two groups (P<0.05). After treatment, the disappearance time of asthma, wheezing, and cough in the treatment group were significantly shorter than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of FEV₁, FVC, and FEV₁/FVC in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, the lung function indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of hs-CRP and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the serum inflammatory factors levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Gushen Dingchuan Pills combined with Budesonide Suspension for inhalation has clinical curative effect in treatment of acute exacerbation of chronic obstructive pulmonary disease, can improve the clinical symptoms, lung function, and serum inflammatory factors levels, with good safety, which has a certain clinical application value.