目的 探讨醒脾养儿颗粒联合复方嗜酸乳杆菌片治疗小儿腹泻的临床疗效。方法 选取2017年4月—2018年4月在河南省三门峡市中心医院进行治疗的94例腹泻患儿，根据用药差别分为对照组和治疗组，每组各47例。对照组患儿口服复方嗜酸乳杆菌片，0～1岁患儿0.25 g/次，大于1岁患儿0.5 g/次，3次/d。治疗组在对照组治疗基础上口服醒脾养儿颗粒，0～1岁患儿2 g/次，2次/d，1～2岁患儿4 g/d，2次/d，3～6岁患儿4 g/次，3次/d。两组患儿均治疗3 d后进行效果比较。观察两组患儿的临床疗效，比较两组临床症状改善时间、T淋巴细胞亚群水平、炎症因子。结果 治疗后，对照组和治疗组的总有效率分别为80.85%、97.87%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患儿腹痛缓解时间、排便恢复正常时间及呕吐缓解时间均显著短于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患儿血清CD3⁺、CD4⁺、CD4⁺/CD8⁺水平均升高，而CD8⁺水平均较治疗前显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组CD3⁺、CD4⁺、CD4⁺/CD8⁺水平高于对照组，但CD8⁺水平低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患儿血清超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均较治疗前显著降低，而白细胞介素-10（IL-10）水平均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组hs-CRP、IL-6、TNF-α水平显著低于对照组，IL-10水平显著高于对照组，两组比较差异有统计学意义（P<0.05）。结论 醒脾养儿颗粒联合复方嗜酸乳杆菌片治疗小儿腹泻具有较好的临床疗效，可有效改善患儿临床症状，提高机体免疫能力，降低机体炎症反应，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of Xingpi Yanger Granule combined with Compound Eosinophil-Lactobacillus Tablets in treatment of infantile diarrhea. Methods Children (94 cases) with infantile diarrhea in Sanmenxia Central Hospital from April 2017 to 2018 April were divided into control (47 cases) and treatment (47 cases) groups according to the difference of drugs. Children in the control group were po administered with Compound Eosinophil-Lactobacillus Tablets, 0.5 g/time for children aged 0-1 year old, 0.5g/time for children aged over 1 year old, 3 times daily. Patients in the treatment group were po administered with Xingpi Yanger Granule on the basis of the control group, 2 g/time for children aged 0-1 year old, twice daily; 4 g/time for children aged 1-2 years old, twice daily; 4 g/time for children aged 3-6 years old, three times daily. Children in two groups were treated for 3 d. After treatment, the clinical efficacy was evaluated, and the changes of clinical symptom improvement time, T lymphocyte subgroup levels, and inflammatory factors in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 80.85% and 97.87%, and there were differences between two groups (P<0.05). After treatment, the relieving time of abdominal pain, the normalizing time of defecation and the relieving time of vomiting in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P<0.05). After treatment, CD3⁺, CD4⁺, CD4⁺/CD8⁺ were significantly increased in two groups, but CD8⁺ were significantly decreased, and there were differences in the same group (P <0.05). After treatment, CD3⁺, CD4⁺, and CD4⁺/CD8⁺ in the treatment group was higher than that in the control group, but CD8⁺ were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, hs-CRP, IL-6, and TNF-α were significantly decreased in two groups, but IL-10 were significantly increased, and there were differences in the same group (P <0.05). After treatment, hs-CRP, IL-6, and TNF-α in the treatment group were lower than those in the control group, but IL-10 were higher than those in the control group, and there were differences between two groups (P<0.05).Conclusion Xingpi Yanger Granule combined with Compound Eosinophil-Lactobacillus Tablets has significant clinical effect in treatment of infantile diarrhea, and can effectively improve the clinical symptoms, and also can improve immune ability, reduce inflammatory response, which has a certain clinical application value.