目的 探讨桂芍镇痫片联合卡马西平片治疗癫痫的临床疗效。方法 选取2017年5月—2018年5月江汉大学附属医院收治的78例癫痫患者为研究对象，所有患者根据治疗方法的不同分为对照组和治疗组，每组各39例。对照组口服卡马西平片，起始剂量0.2 g/次，2次/d，用药7 d后调整剂量，根据病情每周增加0.1～0.4 g，2次/d；治疗组在对照组治疗的基础上口服桂芍镇痫片，6片/次，3次/d。两组患者均连续治疗8周。观察两组的临床疗效，比较两组的癫痫放电、导联数目、癫痫发作次数、血清学指标和认知障碍评分。结果 治疗后，对照组和治疗组的总有效率分别为74.36%、92.31%，两组比较差异有统计学意义（P<0.05）。治疗后，两组癫痫放电、导联数目、癫痫发作次数均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清白细胞介素-2（IL-2）、肿瘤坏死因子-α（TNF-α）、神经元特异性烯醇化酶（NSE）和S100β蛋白（S100β）水平均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组血清学指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组蒙特利尔认知评估量表法（MoCA）评分均显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组MoCA评分明显高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 桂芍镇痫片联合卡马西平片治疗癫痫的临床疗效较好，能改善癫痫症状，提高认知水平，调节血清学指标，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Guishao Zhengxian Tablets combined with Carbamazepine Tablets in treatment of epilepsy. Methods Patients (78 cases) with epilepsy in the Affiliated Hospital of Jianghan University from May 2017 to May 2018 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 39 cases. Patients in the control group were po administered with Carbamazepine Tablets, starting dosage 0.2 mg/time, twice daily, after 7 d, increasing 0.1 to 0.4 g per week according to the condition of the disease. Patients in the treatment group were po administered with Guishao Zhengxian Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and epileptic discharge, lead number, seizure frequency, serological indexes, and cognitive impairment scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 74.36% and 92.31%, respectively, and there was difference between two groups (P<0.05). After treatment, epileptic discharge, lead number and seizure frequency in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05).After treatment, the levels of IL-2, TNF-α, NSE, and S100β in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serological indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, MoCA scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the MoCA scores in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Guishao Zhengxian Tablets combined with Carbamazepine Tablets has clinical curative effect in treatment of epilepsy, can improve the symptoms of epilepsy, improve the level of cognition, and regulate serological indexes, which has a certain clinical application value.