目的 探讨复方甘草酸苷注射液联合他克莫司胶囊治疗过敏性紫癜肾炎的临床疗效。方法 选取2016年5月-2017年5月在十堰市太和医院确诊并接受治疗的过敏性紫癜肾炎患儿104例作为研究对象，将所有患者随机分为对照组（53例）和治疗组（51例）。对照组患儿进食前1 h或进食后2 h口服他克莫司胶囊，0.05 mg/（kg·d），早晚各1次；治疗组在对照组治疗的基础上静脉滴注复方甘草酸苷注射液，年龄 ≤ 3岁时含量控制为10 mL/d，年龄>3岁时为20 mL/d，1次/d。所有患者均连续治疗1个月。观察两组患者的临床疗效，同时比较治疗前后两组的肾功能指标和免疫功能指标。结果 治疗后，对照组和治疗组的总有效率分别为71.7%、84.3%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者24 h尿蛋白、血清肌酐、尿素氮均显著降低，血清白蛋白显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组肾功能指标显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者白细胞介素-16（IL-16）、白细胞介素-18（IL-18）水平均明显下降，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组免疫功能指标水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 复方甘草酸苷注射液联合他克莫司胶囊治疗过敏性紫癜肾炎具有较好的临床疗效，可显著改善患者的肾功能和免疫功能，减轻患儿痛苦，无明显不良反应，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Compound Glycyrrhizin Injection combined with Tacrolimus Capsules in treatment of henoch-schonlein purpura nephritis. Methods Children (104 cases) with henoch-schonlein purpura nephritis in Taihe Hospital of Shiyan City from May 2016 to May 2017 were randomly divided into control (53 cases) and treatment (51 cases) groups. Children in the control group were po administered with Tacrolimus Capsules 1 h before eating or 2 h after eating, 0.05 mg/(kg·d), once in the morning and once in the evening. Children in the control group were iv administered with Compound Glycyrrhizin Injection, and the content was controlled to 10 mL/d at the age of no more than 3 years, 20 mL/d at the age of older than 3, once daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacy was evaluated, and the renal function indexes and the immune function indicators in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 71.7% and 84.3%, respectively, and there were differences between two groups (P<0.05). After treatment, 24 h urinary protein, serum creatinine, and urea nitrogen were significantly decreased, but serum albumin was significantly increased, and there were differences in the same group (P<0.05). After treatment, the renal function indexes were better than those in the control group, and there were differences between two groups (P<0.05). After treatment, IL-16 and IL-18 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the immune function indicators levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Compound Glycyrrhizin Injection combined with Tacrolimus Capsules has clinical curative effect in treatment of henoch-schonlein purpura nephritis, can significantly improve the renal function and immune function of the patients, and alleviate the pain of the children without obvious adverse reactions, which has a certain clinical application value.